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تعداد نتایج: 393 فیلتر نتایج به سال:
miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages
UNLABELLED The intestinal tract is the largest reservoir of microbes in the human body. The intestinal microbiota is thought to be able to modulate alterations of the gut induced by enteropathogens, thereby maintaining homeostasis. Listeria monocytogenes is the agent of listeriosis, an infection transmitted to humans upon ingestion of contaminated food. Crossing of the intestinal barrier is a c...
A hypermethylation defect associated with DNMT hyperactivity and DNMT3b overexpression characterizes a subset of breast cancers and breast cancer cell lines. We analyzed breast cancer cell lines for differential expression of regulatory miRs to determine if loss of miR-mediated post-transcriptional regulation of DNMT3b represents the molecular mechanism that governs the overexpression of DNMT3b...
The mucosal-dominant variant of pemphigus vulgaris (MPV) is an autoimmune disease characterized by oral mucosal blistering and circulating pathogenic IgG antibodies against desmoglein 3 (Dsg3), resulting in life-threatening bullae erosion formation. Recently, microRNAs (miRNAs) have emerged as promising players the diagnosis prognosis several pathological states. For first time, we identified a...
MicroRNAs (miRNAs) regulate gene expression by binding to complementary sequences within target mRNAs. Apart from working ‘solo’, miRNAs may interact in important molecular networks such as competing endogenous RNA (ceRNA) axes. By for a limited pool of miRNAs, transcripts long noncoding RNAs (lncRNAs) and mRNAs can each other, fine-tuning expression. Several ceRNA led different lncRNAs—describ...
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