The 22q11.2 deletion is the strongest known genetic risk factor for schizophrenia. Research has implicated microRNA-mediated dysregulation in 22q11.2 deletion syndrome (22q11.2DS) schizophrenia-risk. Primary candidate genes are DGCR8 (DiGeorge syndrome critical region gene 8), which encodes a component of the microprocessor complex essential for microRNA biogenesis, and MIR185, which encodes mi...

The identification, purification, and biochemical characterization of specific markers for neuroglial cells in the central nervous system is an essential step toward a better understanding of the function of glial cells. This manuscript reports the identification and purification of a neuroglia-associated protein (NAP-185) with an apparent molecular mass of 185 kDa. While its expression is not ...

The dwarf elliptical galaxy NGC 185— the closest early-type galaxy with detectable molecular gas— offers a unique opportunity for high angular resolution studies of the interstellar medium in early-type galaxies. I present interferometric images (17 pc × 14 pc resolution) of CO emission from NGC 185. The majority of the molecular gas in NGC 185 is in one resolved cloud, closely associated with ...

University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, United Kingdom San Diego Supercomputer Center, University of California, San Diego, USA Dipartimento di Informatica, Università di Torino, Corso Svizzera 185, I-10149 Torino, Italy Dipartimento di Sistemi e Informatica, Università di Firenze, Via di S.Marta, 3, I-50139 Firenze 185, Italy [email protected] • [email protected] • locate...

Hemagglutinating Behavior of Mouse and Eggadapted Type A (PR8) Influenza Virus: Seymour S. Kalter .............. ........................ 184 Cytological Evidence Opposing the Theory of Brachymeiosis in the Ascomycetes: Lindsay S. Olive ........... ........................... 185 Inability of Thymine and Adenine to Substitute for Pteroylglutamie Acid in the Folic Acidd4eflient Rat: H. G. Peteri...

Activators of the CFTR Cl- channel may be useful for therapy of cystic fibrosis. Short-circuit current (Isc) measurements were done on human bronchial epithelial cells to characterize the best flavone and benzimidazolone CFTR activators identified by lead-based combinatorial synthesis and high-throughput screening. The 7,8-benzoflavone UCcf-029 was a potent activator of Cl- transport, with acti...

This is in response to recent feedback from our peers that calls for a number of clarifications regarding the experimental section of our paper. Table 1 clarifies which optimizations are used in each evaluated flavor of LegoBase. HyPer-simulated is a configuration of the LegoBase codebase that mirrors the HyPer system as closely as possible by just activating some of the main optimizations and ...