Hepatocellular carcinoma (HCC) is the 5th most common tumour worldwide and has a dark prognosis. For nonoperable cases, metabolic radiotherapy with Lipiodol labelled with β-emitters is a promising therapeutic option. The Comprehensive Cancer Centre Eugène Marquis and the National Graduate School of Chemistry of Rennes (ENSCR) have jointly developed a stable and efficient labelling of Lipiodol w...

BACKGROUND The use of monoclonal antibodies to deliver radioactive isotopes directly to tumor cells has become a promising strategy to enhance the antitumor effects of native monoclonal antibodies. In this article, we summarize the role of radioimmunotherapy in the treatment of leukemia. METHODS The authors reviewed the published clinical trials of radioimmunotherapy in acute leukemia. RESU...

R ecent pre-clinical and clinical studies indicate that irradiation within the dose range of 15 to 30 Gy can reduce the rate of restenosis in patients who have undergone an angioplasty (Nath 1999, King 1998). Several delivery systems of intravascular brachytherapy have been developed to deliver doses within this rang with minimal normal tissue toxicity. One of the possible intravascular irradia...

UNLABELLED Radiopharmaceutical pharmacokinetics are usually approximated by sums of discrete first-order rates, using 3 or more parameters. We hypothesized that pharmacokinetic processes can be modeled even better by continuous probability distributions (CPD) of rates, using only 1-2 parameters. METHODS To test this hypothesis, we used biodistribution data for 188Re-labeled melanin-specific a...