BACKGROUND Cardiac inflammation and generation of oxidative stress are known to contribute to trastuzumab (herceptin) induced cardiac toxicity. Toll-like receptors (TLRs) are a part of the innate immune system and are involved in cardiac stress reactions. Since TLR4 might play a relevant role in cardiac inflammatory signaling, we investigated whether or not TLR4 is involved in trastuzumab induc...

Crossed molecular beam experiments were conducted to investigate the reaction of ground state carbon atoms, C(P j), with 1,2-butadiene, H2CCCH~CH3! (X A8), at three collision energies of 20.4 kJ mol, 37.9 kJ mol, and 48.6 kJ mol. Ab initio calculations together with our experimental data reveal that the reaction is initiated by a barrier-less addition of the carbon atom to the p system of the 1...

The DPD (N, N-diethyl-p-phenylenediamine) is introduced in the present study as an analytical reagent for direct, rapid, easy, and sensitive spectrophotometric detection of hexavalent chromium Cr (VI) species which health hazard. oxidization colorless with results a red color radical (DPD•+) at pH 4.39. intensity directly proportional to concentration. By utilizing UV-Vis spectrophotometer, mea...

The research entitled the "Effect of different nitrogen levels on growth and yield spring maize" was conducted in agriculture farm Lovely Professional University, Phagwara. Three doses used at concentrations from lowest to highest. Nitrogen are denoted as N1, N2 N3 viz 80kgN2ha-1, 120 kg N2ha-1and 160 N2ha-1 respectively. All compared with each other for measurement morphological parameters lik...

Protein phosphorylation plays an important role in the two-component system based signal transduction pathways in bacteria and in archaea. These cascades have been identified also in the extremely halophilic archaeon Halobacterium salinarum and are well understood. Beside these protein phosphorylation events in which phosphorylation of histidine and aspartate residues are crucial, only little i...

The anti-inflammatory peptide annexin-1 binds to formyl peptide receptors (FPR) but little is known about its mechanism of action in the vasculature. Here we investigate the effect of annexin peptide Ac2-26 on NADPH oxidase activity induced by tumour necrosis factor alpha (TNFα) in human endothelial cells. Superoxide release and intracellular reactive oxygen species (ROS) production from NADPH ...

First, the antinociception with the tail-flick test of D-Pro-endomorphin-1 and D-Pro-endomorphin-2 given i.t. was compared with that produced by endomorphin-1 and -2 in male CD-1 mice. High doses of D-Pro-endomorphin-1 (0.2–0.4 pmol) and D-Pro-endomorphin-2 (300–800 pmol) given i.t. produced antinociception with low intrinsic activity [about 25% maximum possible effect (MPE)] compared with that...

Morphological categories of Siberian Turkic numerals are particularly complex and therefore deemed to be especially advantageous to areal investiga tions. The aim of this paper is to see whether (at least some of) the suffixes of collective numerals can readily be used as isogloss connecting Yakut and Dolgan with Tuvinian and Tofalar or, maybe, also some other Turkic languages.

In this paper, we discuss the geometric properties of solution and lower bound estimate of ∆um−1 of the Cauchy problem for a degenerate parabolic equation with periodic source term ut =∆um+ upsint. Our objective is to show that: (1)with continuous variation of time t, the surface ϕ = [u(x,t)]mδq is a complete Riemannian manifold floating in space RN+1and is tangent to the space RN at ∂H0(t); (2...