Case 1 A 39-year-old Japanese man presented with 6-month history of a group of papules on the chest (Figure 1A). The patient had no specific symptoms, such as itching or tenderness, but visited the clinic worried about the long duration of the lesions. Physical examination showed pinkish white, firm papules of 5 to 10 mm in diameter with sharply demarcated borders. The surface of the papules wa...

An 84-year-old woman with hypertension presented to our medical center with dyspnea and lower extremity edema. Electrocardiography demonstrated atrial fibrillation with a rapid ventricular response. Transthoracic echocardiography color Doppler showed abnormal flow in the region of the interatrial septum (Fig. 1A). Transesophageal echocardiography demonstrated a defect adjacent to the interatria...

Figure 1 shows an example of plot generated with GOsummaries package. All the GOsummaries plots have more or less the same layout, however, the elements are adjusted corresponding to the underlying analysis. The plot is built of components (Fig 1A) that represent a gene list or a pair of gene lists as in Fig 1. Each component is composed of two parts the word cloud(s) (Fig 1E), representing the...

A 15-week gestation female fetus was delivered for unexplained intrauterine fetal death. The fetus weighed 125 g and had a crown heel length of 17 cm. Clinical maternal history was unremarkable, with a regular course of gestation until then. At autopsy, no somatic and/or visceral malformations were disclosed. All thoracic and abdominal organs showed initial autolytic changes, the liver was incr...

Chromaffin granules and clathrin-coated vesicles are major sources for V-ATPases of mammalian cells. Studies of these organelles have helped us to understand the structure and function of the enzyme. It was shown that V-ATPases are composed of distinct catalytic and membrane sectors containing several subunits. The subunit stoichiometry was determined to be 3A, 3B, 1C, 1D, 1E, 6c (proteolipids)...

Geospatial technologies like Remote Sensing and Geographical Information Systems (GIS) have been widely used in land resources survey and environmental monitoring. Assessment and monitoring of natural resources like land, soil, water and vegetation and socio-economic conditions and integrating them in a spatial information platform like GIS will facilitate the effective management of land resou...

Four days after cranial trauma, a 41-year-old man presented with fever, headache, confusion, and neck stiffness. He had received antibiotics in an outside hospital for these symptoms. There was no history of CSF rhinorrhea or otorrhea or chronic suppurative otitis media. He underwent cranial diffusion weighted MRI (Figures 1A & 1B), post contrast T1 weighted image (Figure 1C), apparent diffusio...

Mice immunized with recombinant vaccinia virus (VACC) expressing Venezuelan equine encephalitis (VEE) virus capsid protein and glycoproteins E1 and E2 or with attenuated VEE TC-83 virus vaccine developed VEE-specific neutralizing antibody and survived intraperitoneal challenge with virulent VEE virus strains including Trinidad donkey (subtype 1AB), P676 (subtype 1C), 3880 (subtype 1D), and Ever...

Aromatase CYP19 catalyzes the synthesis of estrogen from androgens in a tissue-specific manner. This enzyme is present in several tissues, including gonads, brain and fatty tissue. More recently, its presence has been described in vessels. Here, we describe the expression of aromatase in human uterine artery and compare its expression with that found in arteries of estrogen-dependent uterine le...