Apoptosis, also known as cell suicide or programmed cell death, removes unwanted and genetically damaged cells from the body. Evasion of apoptosis is one of the major characteristic features of rapidly proliferating tumor cells. Chemopreventive agents inhibit or suppress tumor formation through apoptotic induction in target tissues. The aim of the present study was to investigate the pro-apopto...

An attempt was made to separate estrogen from prolactin dependency of 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors at 2.5 and 5 months after DMBA injection. Ovariectomy and drug and/or hormone treatments were used to produce an estrogen or prolactin deficiency for 2 weeks, followed by a 2-week period in which the deficiency was corrected. Tumors were classified as estrogen o...

April June 2017 963 JCPS Volume 10 Issue 2 Chemotherapeutic effect of Ellagic acid encapsulated chitosan nanoparticles on DMBA induced hamster buccal pouch carcinogenesis S. Mirunalini*, V. Arulmozhi and S. Isabella Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar – 608 002 *Corresponding author: E-Mail:[email protected], Tel: 91 4144 238343, Fax: 91 4144 ...

Comparatively little has been published on the use of the hamster in cancer research and only two reports, including some 15 instances, of spontaneous tumors are available (1, 9). The earliest experimental work appears to be Gye and Fould's (9) production of a mixed-cell sarcoma in two males by injecting 3,4-benzpyrene, in 1939. A year later Halberstaedter (11) reported the production of a simi...

The influence of initiator dose and promoter dose, duration, and type on the progression of papillomas to carcinomas was examined in Sencar mice. A good dose-response relationship for promotion of papilloma formation by 12-O-tetradecanoylphorbol-13-acetate (TPA) [following initiation with 6.5 micrograms of 7,12-dimethylbenz(a)anthracene (DMBA)] was observed in the range of 0.125 to 2.0 microgra...

Background and Objective: The fruits of the plant, Choerospondias axillaris are one richest sources flavonoids phenol vitamin C that have been shown to possess a variety biological activities. present study was aimed potential anti-cancer activity methanolic extract fruit using in-vivo model scientifically validate folkloric use axillaris.
 Study Design: In-vivo model.
 Place Duration...

The sensitivity of A/HeJ, AKR/J, C3H/HeJ, C57BL/6J, C58/J, and DBA/2J male mice to single i.p. injections of 7,12dimethylbenz[a]anthracene (DMBA) was investigated. The drug was administered in a single dose of 0.75 to 3 mg per mouse and animals were sacrificed 5-20 days after injection. The AKR mice were least affected by DMBA. Acute ]>eritoneal inflamma tion accompanied by accumulation of an e...

It has been reported that twice-weekly i.p. injections of 4 mg phorbol for 10 weeks, after a single feeding of 6 mg dimethylbenz(a)anthracene (DMBA) in female Wistar rats, led to a significant augmentation of mammary adenocarcinoma incidence and of lymphatic leukemia incidence as compared to 6 mg DMBA alone. In an experiment reported here, in female Sprague-Dawley rats, using the same doses of ...

Breast cancer is the leading cause of new cancer diagnoses among women. Using peroxisome proliferator-activated receptor (PPAR)γ((+/-)) mice, we showed normal expression of PPARγ was critical to stop 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast tumorigenesis. PPARγ is expressed in many breast cell types including mammary secretory epithelial (MSE) cells. MSEs proliferate as required dur...

OBJECTIVE Environmental pollutants are responsible for inducing a number of biochemical and physical changes in the various organs of an organism. The most potent pollutants is7,12-dimethylbenz(α)anthracene (DMBA) (a genotoxic carcinogen), a polyaromatic hydrocarbon. It is known to induce a number of genetic changes including the formation of DNA adducts. These genotypic changes in turn are res...