NOTCH3 gene amplification plays an important role in the progression of many ovarian and breast cancers, but the targets of NOTCH3 signaling are unclear. Here, we report the use of an integrated systems biology approach to identify direct target genes for NOTCH3. Transcriptome analysis showed that suppression of NOTCH signaling in ovarian and breast cancer cells led to downregulation of genes i...

The Notch and transforming growth factor-beta (TGF-beta) signaling pathways play critical roles in the control of cell fate during metazoan development. However, mechanisms of cross-talk and signal integration between the two systems are unknown. Here, we demonstrate a functional synergism between Notch and TGF-beta signaling in the regulation of Hes-1, a direct target of the Notch pathway. Act...

Included in the New Zealand Government’s green paper “ A Future Tertiary Education Policy for New Zealand is the intention to put in place common quality standards, standard methods for reporting programs of study, and a national system to record all students registered in any paper at any tertiary institution. Through the National Qualifications Framework (NQF) the government asserts the right...

since threshing is one of the most sensitive rice post-harvest processing operations, this study was conducted to evaluate the threshing performance in axial - flow paddy thresher. independent variables consisted of: drum speed at five levels (550, 650, 750 and 850 rpm), equivalent to peripheral velocities of: 14.67, 17.35, 20.01 and 22.37 m/s, respectively, paddy moisture content at two levels...

Somatic activating mutations in the Notch1 receptor result in the overexpression of activated Notch1, which can be tumorigenic. The goal of this study is to understand the molecular mechanisms underlying the phenotypic changes caused by the overexpression of ligand independent Notch 1 by using a tetracycline inducible promoter in an in vitro embryonic stem (ES) cells/OP9 stromal cells coculture...

In the developing central nervous system (CNS), Notch signaling preserves progenitor pools and inhibits neurogenesis and oligodendroglial differentiation. It has recently been postulated that Notch instructively drives astrocyte differentiation. Whether the role of Notch signaling in promoting astroglial differentiation is permissive or instructive has been debated. We report here that the astr...

INTRODUCTION Our aims were to analyze adhesion of periodontopathogens to self-ligating brackets (Clarity-SL [CSL], Clippy-C [CC] and Damon Q [DQ]) and to identify the relationships between bacterial adhesion and oral hygiene indexes. METHODS Central incisor brackets from the maxilla and mandible were collected from 60 patients at debonding after the plaque and gingival indexes were measured. ...

The galaxy image pair CSL-1 has been a leading candidate for a cosmic string lens. High quality imaging data from the Hubble Space Telescope presented here show that it is not a lens but a pair of galaxies. The galaxies show different orientations of their principal axes, not consistent with any lens model. We present a new direct test of the straight-string lens model, using a displaced differ...

Analysis 1: Promotions to Brigadier General Is there a relationship between promotion to Brigadier General and resilience? Analysis 2: Below Zone (BZ) Promotions Is BLOCKINthere BLOCKINa BLOCKINrelationship BLOCKINbetween BLOCKINearly BLOCKINField BLOCKINGrade BLOCKINofficer BLOCKINpromotion BLOCKINand BLOCKINresilience? Analysis 3: Selection for a Centralized Selection List (CSL) Key Billet Is...

Continuous Time Markov Chains (CTMCs) are widely used as the underlying stochastic process in performance and dependability analysis. Model checking of CTMCs against Continuous Stochastic Logic (CSL) has been investigated previously by a number of authors [2,4,13]. CSL contains a time-bounded until operator that allows one to express properties such as “the probability of 3 servers becoming fau...