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An efficient method for the synthesis of 3-(1H-indol-3-yl)-2-(7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecan-10-yl)propanoic acid) via condensation 7,8,10,12,13-pentaoxaspiro[5.7]tridecane with tryptophan under action a catalyst based on Sm(NO3)3·6H2O has been developed. A high cytotoxic activity eight-membered azadiperoxide against tumor cells Jurkat, K562, U937, and HL60 was established. Additio...

Kinetic studies with 3,4-dihydroxy-9, IO-secoandrosta1,3,5(10)-triene-9,17-dione-4,5-dioxygenase gave intersecting initial velocity plots that conform to a sequential mechanism. Linear noncompetitive product inhibition patterns were observed with respect to either substrate, indicating the formation of a dead end complex. 4-Isopropyl catechol, a structural analogue of the organic substrate, inh...

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http://www.aic.gov.au Adam Graycar Director Burglary is a significant issue in most urban areas and many agencies are involved in efforts to combat the problem. The police are one such agency that relies on accurate and rigorous analysis of crime and offender data to focus their available resources. The Australian Institute of Criminology has been working with a number of police services to bet...

filaments (Semmes-Weinstein monofilaments). This point localization of sensation (locognosia) was tested by SW filaments over four quadrants of the pulp of the fingers in ulnar/median and ulnar paralysis in 38 new patients affected by leprosy. The results were compared with standard testing of sensation at selected sites by Semmes Weinstein monofilament. Both pulp quadrant testing and standard ...

A fixed-dose pediatric formulation of artesunate and mefloquine (Artequin Pediatric) has been developed. In this open, non-comparative study in Cameroonian children with uncomplicated falciparum malaria, the safety and efficacy of this formulation was tested, with a particular emphasis on the risk of neuropsychiatric adverse events (AEs). In total, 220 subjects, weighing between 10 and 20 kg, w...

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