نتایج جستجو برای: 221 and 334 percent

تعداد نتایج: 16830352  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Annamaria Gullà Maria Teresa Di Martino Maria Eugenia Gallo Cantafio Eugenio Morelli Nicola Amodio Cirino Botta Maria Rita Pitari Santo Giovanni Lio Domenico Britti Maria Angelica Stamato Teru Hideshima Nikhil C Munshi Kenneth C Anderson Pierosandro Tagliaferri Pierfrancesco Tassone

PURPOSE The onset of drug resistance is a major cause of treatment failure in multiple myeloma. Although increasing evidence is defining the role of miRNAs in mediating drug resistance, their potential activity as drug-sensitizing agents has not yet been investigated in multiple myeloma. EXPERIMENTAL DESIGN Here we studied the potential utility of miR-221/222 inhibition in sensitizing refract...

Journal: :Family Medicine & Primary Care Review 2022

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Nykytyuk S, Klymnyuk Panichev V, Marchuk O, Klishch I. Experience of PCR research on Lyme borreliosis in children from the Ternopil Region. Family Medicine & Primary Care Review. 2022;24(4):334-335. doi:10.5114/fmpcr.2022.120857. APA Nykytyuk, S., Klymnyuk, Panichev, V., Marchuk, O., Klishch, (2022). Review, 24(4)...

2015
Shuqi He Renfa Lai Dan Chen Wangxiang Yan Zhaoqiang Zhang Zhiguo Liu Xueqiang Ding Yu Chen

Oral squamous cell carcinoma (OSCC), the most frequent of all oral cancers, is a type of highly malignant tumors with a high capacity to invade locally and form distant metastases. An increasing number of studies have shown that microRNAs (miRNAs) play an important role in regulating cancer metastasis and invasion. In the present study, we detected the expression of miR-221 in two highly metast...

Journal: :Oncology reports 2012
Lingchao Chen Junxia Zhang Lei Han Anling Zhang Chunzhi Zhang Yongri Zheng Tao Jiang Peiyu Pu Chuanlu Jiang Chunsheng Kang

A previous study showed that miR-221/222 can regulate cell apoptosis. p53 is a well known tumor suppressor which can influence the chemosensitivity of glioma cells. However, the effect of miR-221/222 in gliomas with different p53 status is unknown. Here, we demostrate that knockdown of miR-221/222 increases apoptosis in human gliomas of different ...

Journal: :Acta pharmaceutica 2017
Sung-Suk Suh Se Kyung Oh Sung Gu Lee Il-Chan Kim Sanghee Kim

The main aim of the current research was to study the effect of porphyra-334, one of mycosporine-like amino acids (MAAs), well known as UV-absorbing compounds, on UVinduced apoptosis in human immortalized keratinocyte (HaCaT) cells. Due to their UV-screening capacity and ability to prevent UV-induced DNA damage, MAAs have recently attracted considerable attention in both industry and research i...

Journal: :European journal of sport science 2016
Amelia Guadalupe-Grau Lorena Rodríguez-García Rafael Torres-Peralta David Morales-Álamo Jesús Gustavo Ponce-González Ismael Pérez-Suarez Alfredo Santana Jose Al Calbet

OBJECTIVES This study was designed to investigate the association of gender, fibre type composition, and anaerobic performance with the basal skeletal muscle signalling cascades regulating muscle phenotype. DESIGN Muscle biopsies were obtained from 25 men and 10 women all young and healthy. METHODS Protein phosphorylation of Thr(172)AMPKα, Ser(221)ACCβ, Thr(286)CaMKII as well as total prote...

2015
Ryo Yamashita Mitsuo Sato Tomohiko Kakumu Tetsunari Hase Naoyuki Yogo Eiichi Maruyama Yoshitaka Sekido Masashi Kondo Yoshinori Hasegawa

Both pro- and anti-oncogenic roles of miR-221 and miR-222 microRNAs are reported in several types of human cancers. A previous study suggested their oncogenic role in invasiveness in lung cancer, albeit only one cell line (H460) was used. To further evaluate involvement of miR-221 and miR-222 in lung cancer, we investigated the effects of miR-221 and miR-222 overexpression on six lung cancer ce...

Journal: :Journal of the American College of Cardiology 1983

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