نتایج جستجو برای: 222 and 187 tonsha
تعداد نتایج: 16829975 فیلتر نتایج به سال:
Bisdioxopiperazine drugs such as ICRF-187 are catalytic inhibitors of DNA topoisomerase II, with at least two effects on the enzyme: namely, locking it in a closed-clamp form and inhibiting its ATPase activity. This is in contrast to topoisomerase II poisons as etoposide and amsacrine (m-AMSA), which act by stabilizing enzyme-DNA-drug complexes at a stage in which the DNA gate strand is cleaved...
MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally regulate gene expression and have been shown to participate in almost every cellular process. Several miRNAs have recently been implicated in glucose metabolism, but the roles of miRNAs in insulin-resistant conditions, such as obesity or type 2 diabetes, are largely unknown. Herein, we focused on miR-222, the expression o...
MicroRNAs-221 and -222 are highly upregulated in several solid tumors, including melanomas. We demonstrate that the proto-oncogene ETS-1, involved in the pathogenesis of cancers of different origin, is a transcriptional regulator of miR-222 by direct binding to its promoter region. Differently from 293FT cells or early stage melanomas, where unphosphorylated ETS-1 represses miR-222 transcriptio...
MicroRNAs (miRs) are small noncoding RNAs that regulate gene expression primarily through translational repression. In erythropoietic (E) culture of cord blood CD34+ progenitor cells, the level of miR 221 and 222 is gradually and sharply down-modulated. Hypothetically, this decline could promote erythropoiesis by unblocking expression of key functional proteins. Indeed, (i) bioinformatic analys...
mammary secretions of 913 quarters from 229 pregnant holstein heifers were obtained aseptically to determine the prevalence of coagulase-negative staphylococci isolated during periparturient period. quarter samples were collected 14 to 10 days before expected parturition. analysis of culture data indicated that 78.5% (717/913) of samples were negative, 20.5% (187/913) contained coagulase-negati...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Grzywna E, KwiecieÅ J. From the hypertransaminasemia symptoms to recognition of late-onset Pompe disease in a 12-year-old boy. Pediatria Polska - Polish Journal Paediatrics. 2021;96(3):220-222. doi:10.5114/polp.2021.109310. APA Grzywna, E., & KwiecieÅ, (2021). Paediatrics, 96(3), 220-222. https://doi.org/10.5114...
A.N. Andreyev, S. Antalic, D. Ackermann, S. Franchoo, F. P. Heßberger, S. Hofmann, M. Huyse, I. Kojouharov, B. Kindler, P. Kuusiniemi, S. R. Lesher, B. Lommel, R. Mann, G. Münzenberg, K. Nishio, R.D. Page, J. Ressler, B. Streicher, B. Sulignano, P. Van Duppen, and D. Wiseman TRIUMF, 4004 Wesbrook Mall, Vancouver BC, Canada, V6T 2A3; Department of Nuclear Physics, Comenius University, Bratislava...
BACKGROUND MiR-221 and miR-222 are two highly homologous microRNAs whose upregulation has been recently described in several types of human tumors, for some of which their oncogenic role was explained by the discovery of their target p27, a key cell cycle regulator. We previously showed this regulatory relationship in prostate carcinoma cell lines in vitro, underlying the role of miR-221/222 as...
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