in order to achieve prolong corneal contact time of norfloxacin(nfx) for treatment of extra ocular diseases, a ph triggered nanoparticulate in situ gelling system was designed to explore dual advantage of nanoparticles and in situ gelling system, for its ocular delivery. nfx loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-lin...

In this paper, we describe the use of advanced statistical design in the screening experiment to configure parameters and operators of genetic algorithm (GA), which applied to find a shortest distance in a classical travelling salesman problem (TSP). Due to the number of GA parameters, operators and its levels considered in the experiment, the total numbers of program executions required by the...

1. APPLICATION OF FULL FACTORIAL DESIGN IN THE MEASUREMENT OF DRYING RATES OF A ROTARY DRYER Drying is a physical separation process which enables to remove the liquid phase from a solid, semisolid or liquids by means of thermal energy. The aim of the experiment is to observe how various operational parameters affect the drying process in a rotary dryer. In drying process, heat is transferred b...

In k 2 experimental design, the classical fractional factorial designs, the Plackett-Burman designs and the Taguchi orthogonal-array designs all require, with few exceptions, n 2 test conditions, for some k n ≤ . Tsao and Wibowo (2005) pointed out that when only m of the k 2 effects/interactions are non-zero, only m test conditions are required for their estimation. Given the identities of m pr...

This study investigates the effect of some formulation variables on particulate characteristics of poly (DL-lactide-co-glycolide) (PLGA) copolymer nanoparticles by applying 2(3) factorial design and response surface methodology (RSM). Nanoparticles were prepared by solvent displacement technique. Initially, appropriate formulation factors for elaboration of polymeric particles were selected by ...