A series of phthalimide derivatives planned as drugs candidates to treat the symptoms of sickle cell anemia were evaluated in a mutagenicity test using strains of Salmonella typhimurium TA100 and TA102, without and with addition of S9 mixture, with the aim to identify the best structural requirements for a drug candidate without genotoxic activity. The compounds (1,3-dioxo-1,3-dihydro-2H-isoind...

The single crystals of discrete hydrated [(OAc)Cu(mu-hep)(2)Cu(OAc)].2H(2)O (.2H(2)O) and [(OAc)Cu(mu-hep)(2) Cu(O(n)Pr)].2H(2)O (.2H(2)O) (the lattice H(2)O molecules exist as a tetrameric water cluster, hep-H = 2-(2-hydroxyethyl)pyridine), OAc(-) = acetate and O(n)Pr(-) = n-propionate) undergo single-crystal to single-crystal (SCSC) transformations to the dehydrated and , respectively, under ...

a simple and efficient one-pot three-component synthesis of the biologically important spirooxindole-4h-pyrans was carried out by the reaction of isatin, activated methylene reagents, and 4-hydroxycoumarin in aqueous medium. sba-pr-nh2 was found to be an efficient heterogeneous nanoporous solid basic catalyst (pore size of 6 nm) which can be easily handled and removed from the reaction mixture ...

In the title compound, C(15)H(20)O(4)S, a dioxolane ring is fused to the pyran ring of the sugar which carries a thio-phenyl substituent on the anomeric C atom. The dioxolane ring adopts an envelope conformation and the pyran ring system a distorted (4)C(1) chair. The structure is stabilized by O-H⋯O hydrogen bonds, forming centrosymmetric dimers that generate an R(2) (2)(10) ring motif. Additi...

A tunable circularly polarized distributed feedback (DFB) laser based on reflection grating configuration was realized in a solution of 4- (dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran (DCM) doped methanol. Chiral photonic DFB structures with tunable photonic bandgap were generated by controlling the state of polarization of the two interfering pump beams. The dual-peak lasing ...

The title compound C28H22O2, basically consists of three ring systems, viz. a central benzene ring, with a lateral napthalene group to which it subtends a dihedral angle of 66.56 (4)° and a tetra-hydro-pyran ring exhibiting a half-chair conformation. The mol-ecular structure is stabilized by a weak intra-molecular C-H⋯O inter-action, while the crystal packing features weak C-H⋯π contacts.

The title compound, C17H11ClN2O2, which contains two stereogenic C atoms, crystallizes in a centrosymmetric space group as a racemate. The pyran ring and the isoxazole ring adopt sofa and twisted conformations, respectively. The dihedral angle between the benzene ring and the mean plane through the near coplanar atoms of the pyran ring is 4.17 (5)°. The mol-ecular conformation features a weak C...

In the title compound, C(23)H(26)O(4), the two cyclo-hexene rings adopt envelope conformations whereas the pyran ring adopts a boat conformation. In the crystal, pairs of inter-molecular O-H⋯O hydrogen bonds link the mol-ecules into inversion dimers.