In this study, we construct a nonadditive polarizable model potential to describe the intermolecular interactions between carbon tetrachloride, CCl4 , based on classical molecular dynamics techniques. The potential parameters are refined to accurately describe the experimental thermodynamic and structural properties of liquid CCl4 at 298 K. We then carried out additional liquid CCl4 simulations...

Our previous nutrigenomic findings indicate that eggshell membrane (ESM) may prevent liver fibrosis. Here we investigated the effects and mechanisms underlying ESM intervention against liver injury by using DNA microarray analysis and comparative proteomics. In vitro hydrolyzed ESM attenuated the TGFβ1-induced procollagen production of human hepatocyte C3A cells and inhibited the expression of ...

To evaluate the hepatoprotective and in vivo antioxidant effect of aqueous seed extract of Vigna unguiculata (AVU) against Carbon tetrachloride (CCl4) induced hepatic injury in rats. 30 male wistar rats were divided into five groups. Group 1 and 2 received plain groundnut oil (3ml/kg body weight p.o.) for 21 days and had free access to food and water. Group 3, 4 and 5 were pretreated with Silym...

Nanoparticles are important scientific tools that have been recruited in various biotechnological, pharmacological applications. Zinc oxide nanoparticles are used considerably for its catalytic, electrical, optoelectronic and photochemical properties. Quininecontaining anthracycline antibiotic doxorubicin (DXR) has been used for the treatment of a wide variety of cancers, despite of its high an...

BACKGROUND Root of Jurenia dolomiaea is used traditionally in various disorders involving oxidative injuries i.e. rheumatism, gout and as stimulant. Earlier we have investigated in vitro antioxidant and DNA protective ability. In this investigation we have evaluated protective potential of J. dolomiaea root against the oxidative injuries induced with carbon tetrachloride (CCl4) in testes of rat...

BACKGROUND Interferon γ (IFN-γ) increases the expression of multiple genes and responses; however, the mechanisms by which IFN-γ downmodulates cellular responses is not well understood. In this study, the repression of CCL3 and CCL4 by IFN-γ and nitric oxide synthase 2 (NOS2) in macrophages and upon Salmonella typhimurium infection of mice was investigated. METHODS Small molecule regulators a...

The study is designed to evaluate the effect of aqueous extract P. lanceolata plant, as well know drug CCl4 on formation micronucleus in vivo 48 female albino mice. In mice were separated into eight groups treated intraperitoneally for seven day first group Negative control, second positive control( 0.02%), third (250 mg/kg), fourth (500 fifth (CCl4 0.02%) plus sixth seventh mg/kg) and eighth 0...

OBJECTIVE The present study was conducted to investigate the hepatoprotective activity of hydro-ethanolic fruit extract of Rosa canina (R. canina) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. MATERIALS AND METHODS Male Wistar albino rats were randomly divided into six groups of 8 animals of each, including control, toxic (CCl4), R. canina 250, 500, and 750 mg/kg + CCl4 ...

Physalis peruviana (physalis) has long held a place in folk medicine in the tropical countries where it grows. Here, the aim of this study was to evaluate the potential nephroprotective impact of physalis extract against carbon tetrachloride (CCl4)-induced kidney injury and to explore the possible mechanisms by which this plant exerts its beneficial effects. Rats were randomly divided into equa...