نتایج جستجو برای: 3 functionalized imidazoles

تعداد نتایج: 1832131  

2013
Javad Safari Soheila Gandomi-Ravandi Zahra Akbari

An efficient four-component synthesis of 1,2,4,5-tetrasubstituted imidazoles is described by one-step condensation of an aldehyde, benzil, ammonium acetate and primary aromatic amine with nanocrystalline magnesium aluminate in ethanol under ultrasonic irradiation. High yields, short reaction times, mild conditions, simplicity of operation and easy work-up are some advantages of this protocol.

Journal: :Nanoscale 2010
Fiorenzo Vetrone Rafik Naccache Angeles Juarranz de la Fuente Francisco Sanz-Rodríguez Alfonso Blazquez-Castro Emma Martin Rodriguez Daniel Jaque José García Solé John A Capobianco

We report on the efficient incorporation of non-functionalized NaYF(4) : Er(3+), Yb(3+) nanoparticles inside HeLa live cancer cells by direct endocytosis. The efficient two-photon excited near-infrared-to-visible upconversion fluorescence of these nanoparticles is then used to obtain high-contrast intracellular fluorescence images of single cells. These images reveal a redistribution of the nan...

Journal: :Organic & biomolecular chemistry 2012
Timothy J Donohoe Mikhail A Kabeshov Akshat H Rathi Ian E D Smith

A range of heterocycles, namely thiazoles, imidazoles, imidazopyridines, thiazolidines and dimethoxyindoles, have been synthesised directly from alkenes via a two-step ketoidoination/cyclisation protocol. The alkene starting materials are themselves readily accessible using many different and well-established approaches, and allow access to a variety of heterocycles with excellent yields and re...

Journal: :Organic & biomolecular chemistry 2008
Stefan Laufer Pierre Koch

A series of 2-alkylsulfanyl-4-(4-fluorophenyl)-5-(2-aminopyridin-4-yl)-substituted imidazoles was prepared and interaction possibilities of the 2-thioether moiety with phosphate/ribose binding pockets of p38 MAP kinase were investigated. Introduction of the alkyl/benzyl amino function at the pyridine moiety was carried out via nucleophilic substitution or via palladium catalyzed aryl-C-N-bond f...

Journal: :Chemical communications 2015
Yung-Tin Pan Cartney E Smith Kam Sang Kwok Jinrong Chen Hyunjoon Kong Hong Yang

Flexible, charged Pd nanosheets were prepared by using short chain thiolated carboxylic acids and amines. They could wrap around amine or hydroxyl functionalized micron-sized spheres driven by electrostatic interactions. Upon incubation with HepG2 cells, the positively charged cysteamine (CA) functionalized Pd nanosheets exhibited a much higher cytotoxicity, showing more than 80% cell death at ...

Journal: :Chemistry Letters 2021

The ruthenium(II)-catalyzed ortho-C–H arylation of 2-aroyl-imidazoles with aryl bromides and chloride is reported. An imidazole ring functions both as a masked ester directing group for C–H activation. A variety functional groups are tolerated under the reaction conditions. arylated final products could be easily converted into corresponding esters amide.

The present study deals with the synthesis andfunctionalization of mesoporous silica nanoparticles as drug delivery platforms. SBA-15 nanorods with high surface area (1010 m2g-1) were functionalized by post grafting method using 3-mercaptopropyl trimethoxysilane (MPTS). The parent and thiol-functionalized SBA-15 nanorods were used as nanocarriers for an anticancer drug (gemcitabine). The charac...

2012
Barbara Bellei Angela Pitisci Enzo Izzo Mauro Picardo

While investigating the role of p38 MAPK in regulating melanogenesis, we found that pyridinyl imidazole inhibitors class compounds as well as the analog compound SB202474, which does not inhibit p38 MAPK, suppressed both α-MSH-induced melanogenesis and spontaneous melanin synthesis. In this study, we demonstrated that the inhibitory activity of the pyridinyl imidazoles correlates with inhibitio...

Journal: :The Biochemical journal 1966
R B Beechey

1. 30mmum-4,5,6,7-Tetrachloro-2-trifluoromethylbenzimidazole (TTFB) uncouples respiratory-chain phosphorylation. The respiration rate of uncoupled mitochondria is significantly greater than the state 3 rate. Neither added orthophosphate nor ATP is required to sustain this rate. The oligomycin- and octylguanidine-induced inhibitions of respiration are relieved by uncoupling concentrations of TTF...

Javad Safari, Simin Naseh Zahra Akbari Zohre Zarnegar

A simple highly versatile and efficient sonochemical synthesis of 1,2,4,5-tetrasubstituted and 2,4,5-trisubstituted imidazoles is achieved by condensation of 1,2-dicarbonyl compound, aldehyde, ammonium acetate and primary amine using antimony trichloride immobilized on silica gel (SiO2-OSbCl2) as a catalyst in ethanol at moderate temperature. Operational simplicity, practicability and applicabi...

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