Tetrahydroaminoacridine (THA) is a centrally active anticholinesterase that also interacts with neuronal K+ and Na+ channels and cardiac Ca2+ channels. The effects of THA on neuronal voltage-dependent Ca2+ channels are not known. We tested the effects of THA (25 nM-250 microM) on the Ca2+ current components of acutely dissociated rat nodose ganglion and dorsal root ganglion (DRG) neurons using ...

BACKGROUND The relevance of prosthetic component orientation to prevent dislocation and impingement following total hip arthroplasty (THA) has been widely accepted. We investigated the use of a non-computer-based surgery to address the reciprocal orientation of the acetabular and femoral components. METHODS In the femur first technique, the cup is positioned relative to the stem. When the def...

subchondral insufficiency fracture of the femoral head (siffh) is characterized by acute onset hip pain without overt trauma. it appears as a low intensity band with bone marrow edema on t1-weighted mri. the most common course of treatment is protected weight bearing for a period of several weeks. total hip arthroplasty (tha) has been commonly used if the patient does not respond to the initial...

It has been suggested that revision of the femoral component of hip resurfacing after femoral failure would be straightforward and have an outcome comparable to primary total hip arthroplasty (THA). We have compared the outcome of femoral side-only revision resurfacings to the results of primary modular large-bearing metal-on-metal THA. Fourteen consecutive patients underwent revision surgery o...

BACKGROUND Young patients with degenerative cartilage disease of the hip remain a challenge for the orthopaedic surgeon. Different treatment options are available of which uncemented hips are the most popular owing to long-term concerns about cemented implants. As an alternative, we have used a cemented hip design in combination with bone impaction grafting in patients with acetabular defects. ...

BACKGROUND Medical evaluation pre-operatively is an important component of risk stratification and potential risk optimization. However, the effect of timing prior to surgical intervention is not well-understood. We hypothesized that total hip arthroplasty (THA) patients seen in pre-operative evaluation closer to the date of surgery would experience better perioperative outcomes. METHODS We r...

OBJECTIVE To describe age-related differences in outcomes among older adults undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA). DESIGN Retrospective study. PARTICIPANTS A total of 1792 patients who underwent primary THA or TKA at the University of Iowa Hospitals and Clinics between 2010 and 2013 were identified in the University HealthSystem Consortium Database and U...

m r r Feeling was running high this week in the Division of Placement and Unemployment Insurance, as evidence mounted tha t a figure of 300 layoffs might rise to 400. Affected in the first 300 were 149 temporary employees and 30 permanent assistant interviewers in the NYC field offices, and 131 temporary employees in the Albany headquarters offices. Among the "temps" are many former permanent a...

BACKGROUND Both minimally invasive surgery (MIS) and computer-assisted surgery (CAS) for total hip arthroplasty (THA) have gained popularity in recent years. We conducted a qualitative and systematic review to assess the effectiveness of MIS, CAS and computer-assisted MIS for THA. METHODS An extensive computerised literature search of PubMed, Medline, Embase and OVIDSP was conducted. Both ran...

BACKGROUND Excessive pelvic tilt may be one of the factors leading to instability in total hip arthroplasty (THA), even when the acetabular cup is placed properly. To our knowledge, only a few studies have described late anterior dislocation due to posterior pelvic tilt. We present 3 cases with late anterior dislocations possibly due to posterior pelvic tilt. CASES PRESENTATIONS Case-1: An 84...