Kink turns (k-turns) are widespread elements in RNA that mediate tertiary contacts by kinking the helical axis. We have found that the ability of k-turns to undergo ion-induced folding is conferred by a single base pair that follows the conserved A·G pairs, that is, the 3b·3n position. A Watson-Crick pair leads to an inability to fold in metal ions alone, while 3n=G or 3b=C (but not both) permi...

Abstract Genome-wide association studies linked expression of the human neutrophil antigen 3b (HNA-3b) epitope on Slc44a2 protein with a 30% decreased risk venous thrombosis (VT) in humans. is ubiquitous transmembrane identified as receptor for von Willebrand factor (VWF). To explain link between and VT, we wanted to determine how expressing either HNA-3a or HNA-3b neutrophils could modulate th...

Tetraphenylethene (TPE) substituted phenanthroimidazoles 3a and 3b were designed and synthesized by the Suzuki cross-coupling reaction. They show reversible mechanochromic behavior with contrast colors between sky-blue and yellow green. The powder XRD studies show that destruction of a crystalline state into an amorphous state is responsible for mechanochromism. Hydrogen bonding interaction of ...

The 5-upstream region of a winged bean chymotrypsin inhibitor gene (JVCI-3b) was found to have a high affinity for nuclear matrix. The region, named WCI-3b MAR (matrix attachment region), is highly A + T-rich and contains multiple sites interacting with nuclear matrix. A MAR was also found in the corresponding region of the WCI-x gene, another active gene of the WCI family. Several MAR-binding ...

A, androstenedione Arom, aromatase AMH, anti Müllerian hormone cAMP, adenosine 3': 5'cyclic monophosphate DHT, dihydrotestosterone E, estrogen E1, estrone E2, estradiol 17B ER, estrogen receptor FT, female-producing temperature 3B-HSD, 3B-hydroxysteroid dehydrogenase-5-ene-4-ene isomerase 17B-HSD, 17B-hydroxysteroid dehydrogenase hsp, heat-shock protein MT, male-producing temperature P 450 arom...

NEUROSCIENCE Correction for “Restoring the sense of touch with a prosthetic hand through a brain interface,” by Gregg A. Tabot, John F. Dammann, Joshua A. Berg, Francesco V. Tenore, Jessica L. Boback, R. Jacob Vogelstein, and Sliman J. Bensmaia, which appeared in issue 45, November 5, 2013, of Proc Natl Acad Sci USA (110:18279–18284; first published October 14, 2013; 10.1073/ pnas.1221113110). ...

Compared with our growing understanding of the organization of somatosensory cortex in monkeys, little is known about prosimian primates, a major branch of primate evolution that diverged from anthropoid primates some 60 million years ago. Here we describe extensive results obtained from an African prosimian, Galago garnetti. Microelectrodes were used to record from large numbers of cortical si...

This study mapped the fine-scale functional representation of tactile and noxious heat stimuli in cortical areas around the central sulcus of anesthetized squirrel monkeys by using high-resolution blood oxygen level-dependent (BOLD) fMRI at 9.4T. Noxious heat (47.5°C) stimulation of digits evoked multiple spatially distinct and focal BOLD activations. Consistent activations were observed in are...

Rabbit skeletal muscle glycogen synthase, a rate-limiting enzyme for glycogen biosynthesis, is regulated by multisite phosphorylation. The protein kinase glycogen synthase kinase 3 (GSK-3) phosphorylates 4 Ser residues (Ser-640, Ser-644, Ser-648, and Ser-652; also known as sites 3a, 3b, 3c, and 4, respectively) at the COOH terminus of the subunit. Phosphorylation of these sites by GSK-3 is sequ...

The major part of the gene inlB was sequenced in 24 strains of Listeria monocytogenes belonging to serovars 1/2a, 1/2b, 1/2c, 3b and 4b. A phylogenetic analysis based on the inlB nucleotide sequences showed that strains of serovars 1/2a and 1/2c were closely related, as well as those of serovars 1/2b and 3b. Strains sharing serovar 4b could be divided into two distinct groups. There were differ...