MOTIVATION There are two main areas of difficulty in homology modelling that are particularly important when sequence identity between target and template falls below 50%: sequence alignment and loop building. These problems become magnified with automatic modelling processes, as there is no human input to correct mistakes. As such we have benchmarked several stand-alone strategies that could b...

This paper describes a technique for determining the position of the friction stir welding (FSW) tool with respect to the weld seam during welding. This technique is proposed for online misalignment detection or as a position estimator for in-process tracking of the weld seam for FSW.

3D modelling and animation software is typically operated via single-pointer input, imposing a serialised workflow that seems cumbersome in comparison to how humans manipulate objects in the real world. Research has brought forth new interaction techniques for modelling and animation that utilise input with more degrees of freedom or employ both hands to allow more parallel control, yet these a...

Asymmetric cell division is critical during development, as it influences processes such as cell fate specification and cell migration. We have characterized FRK-1, a homolog of the mammalian Fer nonreceptor tyrosine kinase, and found it to be required for differentiation and maintenance of epithelial cell types, including the stem cell-like seam cells of the hypodermis. A genomic knockout of f...

Conventional two dimensional(2D) maps and DTMs are insufficient to represent geographic information in urban space comprising high-rise buildings and underground structures. There is a pressing need for a model of three dimensional(3D) representation of urban space, that is, a Digital Urban Space Model(DUSM). However, existing solid modelling techniques cannot be directly applied to the 3D repr...

In gen(-, ral ,a seam may f ai I as a result of longitudinal or transverse loading. Previous workers have reported transverse seam strength to be a prime requirement in most cases of Joining woven fabrics by the means of sewn seams. Transverse seam breaks can be divided into two types: Type I in which only the sewinq thread breaks (with Lhe fabric undamaged); and Irype II in which only the fabr...

BACKGROUND The development of a connection between the uterus and the vulva in the nematode Caenorhabditis elegans requires specification of a uterine cell called the utse, and its attachment to the vulva and the epidermal seam cells. The uterine pi cells generate the utse and uv1 cells, which also connect the uterus to the vulva. The uterine anchor cell (AC) induces the vulva through LIN-3/epi...

The Caenorhabditis elegans GATA transcription factor elt-1 has previously been shown to have a central role in the specification of hypodermal (epidermal) cell fates and acts several cell divisions before the birth of hypodermal cells. Here we report that elt-1 also has essential functions during subsequent development. Reporter gene studies show that elt-1 expression is maintained in lateral s...