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To elucidate the significance of tRNA modification for human lymphoid maturation and malignant transformation, the amount of tRNAs having guanosine in place of queuosine, i.e., (Q-)tRNA, was determined in several human lymphomas and leukemias by exchanging the respective unmodified guanosine residue for [3H]guanine, a reaction catalyzed by a specific tRNA transglycosylase from Escherichia coli....

To elucidate the significance of tRNA modification for human lymphoid maturation and malignant transformation, the amount of tRNAs having guanosine in place of queuosine, i.e., (Q-)tRNA, was determined in several human lymphomas and leukemias by exchanging the respective unmodified guanosine residue for [3H]guanine, a reaction catalyzed by a specific tRNA transglycosylase from Escherichia coli....

Cholecystokinin (CCK) is a growth factor for normal pancreas. Nu merous studies also suggest that CCK promotes pancreatic carcinogenesis in the rat. Our previous studies suggested that growth of preneoplastic pancreatic foci was stimulated by CCK more than that of normal pan creas. We hypothesized that such differential growth might be due to increased numbers of CCK receptors in neoplastic tis...

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semantics: k-CFA ((f e), β̂, σ̂, â) ; (e′, β̂′, σ̂′, â′), where Ê(f, β̂, σ̂) ∋ 〈(λ (x) e′), β̂′′〉 â′ = ⌊l · â⌋k Ê(e, β̂, σ̂) = d̂ β̂′ = β̂′′[x 7→ â′] σ̂′ = σ̂ ⊔ [â′ 7→ d̂] And: Ê(x, β̂, σ̂) = σ̂(β̂(x)) Ê((λ (x) e), β̂, σ̂) = {〈(λ (x) e), β̂〉} Resolving and Exploiting the k-CFA Paradox, New England Programming Language and Systems Sysmposium, MIT, December, 2009 – p.5/22 The Paradox of k-CFA Resolving and Exploiting ...

Low dose cyclophosphamide (CY) can augment the development of delayed-type hypersensitivity to primary antigens in patients with ad vanced cancer. In this paper, we have considered the hypothesis that the immunopotentiation is related to reduction of T-suppressor activity. Peripheral blood lymphocytes were collected and cryopreserved from 45 patients with metastatic malignancy before and then 3...

to be useful in practice (Felkenes, 1980). When ethical decision-making and the organization have been studied empirically, researchers found that those who rely on organizational rules deliberate somewhat differently on ethical issues than do those practitioners who use ethical principles to guide their decision-making (Kugelman-Jaffee, 1990). Thus, the challenge for hospital based social wo...

Topotecan, a water-soluble semisynthetic analogue of camptothecin, is the first topoisomerase I inhibitor to undergo evaluation in pediatrie patients with refractory malignancies. A phase I and pharmacokinetic study was performed to determine the maximum tolerated dose (MTD) and dose-limiting toxicities, the incidence and severity of other toxicities, and the pharmacokinetics of topotecan in ch...

Ú ̆ ‰ ‡ Ï , È Â ‡ · was an active, if not the most active, character throughout „ Â „ ’s reign. However, the character of È Â ‡ · and his brothers is foggy and puzzling. Although many of us have been taught to classify figures in Tanach into the roles of either ¢ ˆ „ È ̃ ¢ or ¢ ̄ ̆ Ú ¢ to further our understanding of the manifest context © Ù ̆ Ë ® and latent meaning © „ ̄ ̆ ® of the text, È Â ‡ · and ...