c-Src kinase activity is regulated by phosphorylation of Y527 and Y416. Y527 phosphorylation stabilizes a closed conformation, which suppresses kinase activity towards substrates, whereas phosphorylation at Y416 promotes an elevated kinase activity by stabilizing the activation loop in a manner permissive for substrate binding. Here we investigated the correlation of Y416 phosphorylation with c...

Harald Derschka (Bearb.), Quellen zur Wirtschaftsgeschichte der Abtei Reichenau aus Zeit Johann Pfusers von Nordstetten als Großkeller (1450 – 1464) und Abt (1464 1491). Gedenkbuch Urbare Ordnungen (Veröffentlichungen Kommission für geschichtliche Landeskunde in Baden-Württemberg A 64). Ostfildern: Thorbecke 2022. 416 S. ISBN 978-3-7995-9564-3. Geb. € 35,–

Freiheit – Wahrheit Evangelium. Reformation in Württemberg, bearb. von Peter Rückert unter Mitarbeit Alma-Mara Brandenburg und Eva-Linda Müller, hg. vom Landesarchiv Baden-Württemberg, Ostfildern: Thorbecke 2017. 2 Bände. Katalog: 416 S., zahlr. Abb. ISBN 978-3-7995-1234-3, Beiträge: 336 978-3-7995-1233-6. € 55,–

Cervical cancer is one of the leading causes of cancer deaths among women globally and its impact is mostly felt in developing countries like Uganda where its prevalence is higher and utilization of cancer screening services is low. This study aimed to identify factors associated with intention to screen for cervical cancer among women of reproductive age in Masaka Uganda using the attitude, so...

BACKGROUND DTS-108 is a hydrosoluble prodrug, where the SN-38 moiety is covalently linked to a 20-amino acid vector peptide by a specific esterase-sensitive cross-linker, releasing 7-ethyl-10-hydroxycampthotecin (SN-38) by esterase bond cleavage. METHODS The pharmacokinetics of DTS-108, adverse events graded according to NCI-CTCv3.1, dose-limiting toxicities at cycle 1, the maximum tolerated ...

Two interacting galaxies and four central galaxies in cooling flow clusters were observed with the Hubble Space Telescope to look for young compact massive star clusters. The two interacting galaxies, NGC 3597 and NGC 6052, show clear evidence for resolved bright blue clusters that are likely to be comparable in mass to Galactic globulars based on their colors and brightnesses. In NGC 3597, the...

Abstract Purpose The first step in typical treatment of vestibular schwannoma (VS) is to localize the tumor region, which time-consuming and subjective because it relies on repeatedly reviewing different parametric magnetic resonance (MR) images. A reliable, automatic VS detection method can streamline process. Methods convolutional neural network architecture, namely YOLO-v2 with a residual as...

We exploit multi-band Hubble Space Telescope photometry to investigate multiple populations (MPs) along the red horizontal branches (HBs) and clumps of fourteen metal-rich Globular Clusters (GCs), including twelve Milky Way GCs Magellanic Cloud NGC 1978 416. Based on appropriate two-color diagrams we find that fraction 1G stars in Galactic correlates with cluster mass, confirming previous resul...

Introducción: La Retinopatía del Prematuro (ROP) es una de las principales causas ceguera prevenibles en la infancia. Fundación Visión implementa; el Programa Prevención, Detección y Tratamiento año 2015.
 Objetivos: Describir los resultados implementación alcanzados por un programa ROP su accesibilidad, efectividad calidad atención.
 Materiales Métodos: Estudio descriptivo, ambispect...