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BACKGROUND The aim of the study was to explore Fc mutations of a humanised anti-Lewis-Y antibody (IgG1) hu3S193 as a strategy to improve therapeutic ratios for therapeutic payload delivery. METHODS Four hu3S193 variants (I253A, H310A, H435A and I253A/H310A) were generated via site-directed mutagenesis and radiolabelled with diagnostic isotopes iodine-125 or indium-111. Biodistribution studies...
The Snaer program calculates the posterior mean and variance of variables on some of which we have data (with precisions), on some we have prior information (with precisions), and on some prior indicator ratios (with precisions) are available. The variables must satisfy a number of exact restrictions. The system is both large and sparse. Two aspects of the statistical and computational developm...
Premature delivery is still a significant problem in obstetrics, and chorioamnionitis is an unwelcome complication. C-reactive protein (CRP) is a circulating marker of low-grade inflammation and the role of its measurement in clinical practice remains unclear for many conditions. It has been claimed that estimation of CRP is helpful in the diagnosis of chorioamnionitis, and this study aims to a...
In order to explain how and why talent management can contribute to a firm’s sustained competitive advantage, we need to gain insights into the philosophies about talent that underpin talent management. This article introduces four talent philosophies that vary in their perception of talent as (a) rare (exclusive) or universal (inclusive), and (b) stable or developable: the exclusive/stable; ex...
This paper aims to develop the multi-agent based simulation model which considered the evacuees’ cognition to the crowd. This model defines an evacuee as an agent, who collects information from surroundings, such as a road, cross, damaged structure and situation of the crowd. Furthermore, this model constructs a simulation platform which enables to act agent autonomously. Our simulation model f...
radioimmunotherapy (rit) of non-hodgkin’s lymphoma (nhl) is said to be more advantageous compared to unlabelled therapeutic antibodies. to this date, radiolabelled murine anti-cd20 mabs, zevalin® and bexxar® have been approved for imaging and therapy. a preparation containing rituximab, chimeric mab radioimmunoconjugate suitable for lu-177 labeling, could provide better imaging and therapeutic ...
مقدمه: نقش رسپتورهای تیروزین کینازی در پاتوژنز سرطان کولون در رده های سلول سرطانی و نمونه های توموری متعددی ارزیابی شده است. از بین آنها افزایش بیان رسپتور igf-1r مرتبط با پیش آگهی بد، ترانسفورماسیون، متاستاز، آنژیوژنز و مقاومت به درمانهای رایج در سرطان کولون است. وقتی sirna ضد igf-1r با یک رادیوایزوتوپ همراه می گردد، sirna فرایند rnai را در سلولهاد القاء کرده و خاموش سازی ژن مورد نظر انجام می ...
A single tool for early detection, accurate staging, and personalized treatment of prostate cancer (PCa) would be a major breakthrough in the field of PCa. Gastrin-releasing peptide receptor (GRPR) targeting peptides are promising probes for a theranostic approach for PCa overexpressing GRPR. However, the successful application of small peptides in a theranostic approach is often hampered by th...
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