نتایج جستجو برای: 5 فریتهوف شوان

تعداد نتایج: 1215812  

2015
Hideharu Hashimoto June E. Pais Nan Dai Ivan R. Corrêa Xing Zhang Yu Zheng Xiaodong Cheng

The family of ten-eleven translocation (Tet) dioxygenases is widely distributed across the eukaryotic tree of life, from mammals to the amoeboflagellate Naegleria gruberi. Like mammalian Tet proteins, the Naegleria Tet-like protein, NgTet1, acts on 5-methylcytosine (5mC) and generates 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in three consecutive, Fe(I...

Journal: :Methods in enzymology 2012
Li Shen Yi Zhang

One of the most exciting recent advances in the epigenetic field is the discovery that 5-methylcytosine (5mC) in DNA can be iteratively oxidized by a family of proteins known as Tet proteins to generate 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). These 5mC derivatives can be further processed by thymine-DNA glycosylase (TDG) followed by base excision r...

2013
Xi-Wen Xing Yu-Li Liu Mario Vargas Yinsheng Wang Yu-Qi Feng Xiang Zhou Bi-Feng Yuan

5-methylcytosine (5-mC) can be sequentially oxidized to 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-foC), and finally to 5-carboxylcytosine (5-caC), which is thought to function in active DNA cytosine demethylation in mammals. Although the roles of 5-mC in epigenetic regulation of gene expression are well established, the effects of 5-hmC, 5-foC and 5-caC on DNA replication remain uncl...

Journal: :Journal of Neurogastroenterology and Motility 2015

Journal: :American Journal of Economics and Business Administration 2011

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