Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion and diffusion magnetic resonance imaging every 30 minutes for 3 hours. The normal left-hemisphere apparent diffusion coefficient (ADC) was 0.76 +/- 0.03 x 10(-3) mm(2)/s and CBF was 0.7 +/- 0.3 mL x g(-1) x min(-1) (mean +/- SD, n=5). The ADC and CBF viability ...

25 Low pressure-gas chromatography (LP-GC) has been applied during the last few 26 years for the fast analysis of various pollutants in different environmental and food matrices. 27 A typical LP-GC setup involves the use of a short microbore column (typically 0.5-1 m x 28 0.10 mm internal diameter) at the injector side connected with a zero dead-volume connector 29 to a short megabore column (t...

Phosphorus (P) loss in overland flow varies with spatial distribution of soil P, management, and hydrological pathways. The effect of flow time, flowpath length, and manure position on P loss in overland flow from two central Pennsylvania soils packed in boxes of varying length (0.5, 1.0, 1.5, 2.75, and 4.0 m long x 15 cm wide x 5 cm deep) were examined by collecting flow samples at 5-min inter...

Transepithelial fluid transport (Jv) and intracellular Na+ and Cl- activities (aNai, aCli) were measured in isolated Necturus gallbladders to establish the contribution of different proposed apical membrane entry mechanisms to transepithelial salt transport. In 10 mM HCO3-Ringer's, Jv was 13.5 +/- 1.1 microliter X cm-2 X h-1, and was significantly reduced by a low bicarbonate medium and by addi...

We have produced 5 x 5 pixel arrays of microcalorimeters using bulk micromachining. Analysis of our data provides the thermal conductivity parameters of SixNy I p m thick membranes at 100 mK. Moreover wefind that the thermal transport at 100 mK in Si beams, with dimensions 1.25 mm x 0.35” x 35pm (length x height x width) is dominated by ballistic phonons with a mean free path of 110 pn. These t...

The CDK inhibitor SNS-032 had previously exerted promising anti-neuroblastoma activity via CDK7 and 9 inhibition. ABCB1 expression was identified as major determinant of SNS-032 resistance. Here, we investigated the role of ABCB1 in acquired SNS-032 resistance. In contrast to ABCB1-expressing UKF-NB-3 sub-lines resistant to other ABCB1 substrates, SNS-032-adapted UKF-NB-3 (UKF-NB-3rSNS- 032300n...

In the ROSAT era of the mid-1990’s, the problems facing deep X-ray surveys could be largely solved with 10 m class telescopes. In the first decade of this new millennium, with X-ray telescopes such as the Chandra X-ray Observatory and XMM-Newton in operation, deep X-ray surveys are challenging 10 m telescopes. For example, in the Chandra Deep Field surveys, ≈ 30% of the X-ray sources have optic...

Tunnelling in urban areas is growing response to efficient transportation, many tunnels are constructed soft ground at shallow depths. Urban usually as twin-parallel and their adjacent constructions may cause settlements that distort damage the existing structures utilities above tunnel. In past few decades, tunnel boring machines have been used drill increasingly difficult geotechnical conditi...

We have developed and characterized cell-free systems active in translation from unfertilized eggs, 30-min zygotes and hatched blastulae of the sea urchin Strongylocentrotus purpuratus. The ion concentrations selected for preparation of the lysates were 150 mM-K+, 40 mM-Na+, 40 mM-Cl-, 5 x 10(-7) M free Ca2+ and 1 mM free Mg2+. It was necessary to include the ribonuclease inhibitor RNas in the ...

High energy x-ray beam penumbra are measured using Gafchromic EBT film. Gafchromic EBT, due to its limited energy dependence and high spatial resolution provide a high level of accuracy for dose assessment in penumbral regions. The spatial resolution of film detector systems is normally limited by the scanning resolution of the densitometer. Penumbral widths (80%/20%) measured at Dmax were foun...