there has been special interest in the chemistry of quinolone and pyrimidine derivatives due to their diverse biological activities such as anticonvulsant, anti-malarial agents, antibacterial, antiviral, cytostatic, antithelemintic, antigenotoxic, anti-cancer agents. these compounds are also used as targeting delayed-type hypersensivity and anti-convulsant agents. as a part of our research work...

A second, monoclinic, polymorph of the title compound, C19H19N3O, is reported. In this polymorph, the molecules are linked into chains by paired C-H...pi hydrogen bonds and the chains are linked into sheets by pi stacking interactions.

Angiotensin-converting enzyme inhibitors limit infarct size in animal models of myocardial ischemia reperfusion injury. This effect has been shown to be due to inhibition of bradykinin degradation rather than inhibition of angiotensin II formation. The purpose of this study was to determine whether angiotensin AT1 receptor blockade by losartan or its active metabolite EXP3174 protects against m...

Tetrahydrocarbazoles are important class of heterocycles that exhibit numerous biological properties. They also found in several natural products. In the present study, Fischer indolization L-menthone was investigated for diastereoselectivity using different reaction conditions. No appreciable observed acids used except CuBr and boric acid at varying temperatures, where satisfactory results wer...

5-Lipoxygenase (LOX) is an important arachidonic acid-metabolizing enzyme producing leukotrienes and other proinflammatory lipid mediators with potent pathophysiological functions in asthma and other inflammatory diseases. 4-(3-(4-(1-Methyl-1H-pyrazol-5-yl)phenylthio)phenyl)-tetrahydro-2H-pyran-4-carboxamide (PF-4191834) is a novel, selective non-redox 5-lipoxygenase inhibitor effective in infl...

Fruit of Carissa opaca Stapf ex Haines (C. opaca) is a feed additive and commonly used against cardiac dysfunction, fever, asthma, diarrhea, gastrointestinal ailments, skin diseases. In this study, we aimed to evaluate the metabolic profile antioxidant potential C. fruit carbon tetrachloride (CCl4)-induced cardiotoxicity testicular toxicity in rats. Gas Chromatoghraphy-Mass Spectrometry (GC-MS)...