Cholesterol efflux occurs by different pathways, including transport mediated by specific proteins. We determined the effect of enriching cells with free cholesterol (FC) on the release of FC to human serum. Loading Fu5AH cells with FC had no effect on fractional efflux, whereas enriching mouse peritoneal macrophages (MPMs) resulted in a doubling of fractional efflux. Efflux from cholesterol-no...

The urokinase receptor (uPAR) binds and localizes urokinase activity at cellular surfaces, facilitating fibrinolysis and cellular migration at sites of tissue injury. uPAR also participates in cellular signaling and regulates integrin-dependent adhesion and migration in vitro. We now report evidence that uPAR occupancy regulates cellular migration in vivo in the absence of functional urokinase....

Copper (Cu) foams with high porosity of about 63–78% were processed by the freeze-casting (FC) and space-holder (SH) methods. The FC SH techniques yielded lamellar polygonal pore structures, respectively, similar porosities. deformation behaviors two different types Cu compared using uniaxial compression a simultaneous acoustic emission (AE) video recording analysis. It was found that compressi...

We have established that, in mice receiving donor-specific immunization by the portal vein, the increased graft survival seen is associated with the increased expression of a molecule (OX-2) on a subpopulation of dendritic cells (DC), and polarization of cytokine production to type 2 cytokines on Ag-specific restimulation of cells from these mice. Furthermore, infusion of a mAb to OX-2 blocks b...

KIT is a cell surface tyrosine kinase receptor whose ligand stem cell factor (SCF) triggers homodimerization and activation of downstream effector pathways involved in cell survival, proliferation, homing, or differentiation. KIT-activating mutations are major oncogenic drivers in subsets of acute myeloid leukemia (AML), in mast cell leukemia, and in gastrointestinal stromal tumors (GIST). The ...

The influence of seed priming with varying levels (50 and 100 mg L?1) alpha-tocopherol (Toc) was investigated in carrot plants under water-deficit conditions. For this purpose, two cultivars carrot, DC4 DC90, were selected subjected to well-watered (100% field capacity (FC)) stress (50% FC). After 21 days conditions, a significant suppression observed shoot root fresh dry weights, their lengths...

Functional connectivity (FC) patterns obtained from resting-state functional magnetic resonance imaging data are commonly employed to study neuropsychiatric conditions by using pattern classifiers such as the support vector machine (SVM). Meanwhile, a deep neural network (DNN) with multiple hidden layers has shown its ability to systematically extract lower-to-higher level information of image ...