BACKGROUND Platelet adhesion and subsequent thrombus formation on a subendothelial matrix at the site of vascular damage play a crucial role in the arrest of posttraumatic bleeding but also in different pathological thrombotic events, such as acute coronary syndrome and stroke. Recently published studies have clearly demonstrated that platelet integri alphaIIbbeta3 is intimately involved in the...

The horizontal and vertical structure of unusually warm and dry spells (WDS) over the central parts of South America during the winter and post-winter months (JJAS) are studied. During WDS the mean temperature and humidity anomalies over central Brazil are about +4.1C and −13.2%, respectively. The mean duration of WDS is 11 days and their mean frequency is less than one per year during the mont...

Background: Platelet adhesion and subsequent thrombus formation on a subendothelial matrix at the site of vascular damage play a crucial role in the arrest of posttraumatic bleeding but also in different pathological thrombotic events, such as acute coronary syndrome and stroke. Recently published studies have clearly demonstrated that platelet integri αIIbβ3 is intimately involved in the occlu...

Progress in treatment for cancer has enabled extension of the disease-free interval, and of the quality of life for patients, but there has been very little improvement in overall survival rates. The main reason for this has been the ineffectiveness of current therapies to kill all the cancer cells once they have spread to distant sites to form metastatic deposits. One marker which has proved t...

Until now, climate model intercomparison has focused primarily on annual and global averages of various quantities or on specific components, not on how well the general dynamics in the models compare to each other. In order to address how well models agree when it comes to the dynamics they generate, we have adopted a new approach based on climate networks. We have considered 28 pre-industrial...

Using the Goddard Laboratory for Atmospheres Goddard Earth Observing System-1 analyses, the horizontal distribution of atmospheric forcing processes involved in the growth, maintenance, and decay of two Northern Hemisphere midlatitude blocking anticyclones that occurred simultaneously were examined, with the goal of determining whether there was a dynamic connection between the two cases. The c...

Immunization against the human platelet antigen (HPA)-1 alloantigen is the most common cause of severe fetal and neonatal thrombocytopenia. Fetal therapy has substantial risks and its indications need better definition. Of 24,417 consecutive pregnant women, 618 (2.5%) were HPA-1a negative of whom 385 entered an observational study. All were HLA-DRB3*0101 genotyped and screened for anti-HPA-1a. ...

To further verify the ozone profile reliability of satellite remote sensing for the ozone valley over the Tibetan Plateau in the core area of the South Asian high in summer, we validate the ozone products from the microwave limb sounder (MLS) onboard the Aura satellite over the Tibetan plateau using electrochemical concentration cell (ECC) ozonesonde data of 2016 for Ngari, Tibet. The MLS versi...

BACKGROUND The aim of the present study was to investigate the expression of glucose-related protein 78 (GRP78) and heparanase (HPA) in oral squamous cell carcinoma (OSCC) and their relationship with clinicopathological parameters and potential implications for survival. METHODS A total of 46 patients with OSCC and 10 normal individuals were recruited for the study. GRP78 and HPA expression w...