A highly sensitive method for the detection of avian influenza virus (AIV) antigen by the resonance light scattering (RLS) technique has been developed in this paper. Magnetic silica nanoparticles (MNs) were modified with AIV antibody via covalent binding firstly, the MNs/AIV antibody-AIV antigen immunocomplex was formed after the addition of AIV antigen, which can increase the RLS signal at 54...