Randomized clinical trials showed that maintenance chemotherapy plus biologics in patients with mCRC could increase the progression free survival (PFS) without any advantage for overall (OS). Our aim was to study real-life experience (onco-colon registry Turkey) of antiEGFR or antiVEGF mAbs after standart firstline doublet backbone RAS wild-type patients. This multicenter, retrospective aimed e...

QUESTION What is the optimal chemotherapy regimen in advanced gastric cancer? PERSPECTIVES Gastric cancer is the second leading cause of cancer mortality worldwide. Despite low incidence rates for gastric cancer in Ontario, the overall prognosis is bleak, with 5-year survival rates of approximately 23% in Canada. Even with the considerable body of research available on chemotherapy for advanc...

PURPOSE Low-molecular weight (LMW) chemotherapeutics are believed to reach tumors through diffusion across capillary beds as well as membrane transporters. Unexpectedly, the delivery of these agents seems to be augmented by reductions in tumor interstitial fluid pressure, an effect typically associated with high-molecular weight molecules that reach tumors principally through convection. We inv...

BACKGROUND Disseminated intravascular coagulation associated with malignant bone marrow involvement has been described as a rare complication of gastric carcinoma and most patients die within 1-4 weeks. Effective chemotherapy of the underlying malignancy may be the only way to control acute DIC. OBJECTIVES To assess the benefit of infusional 5-fluorouracil as the primary treatment of metastat...

PURPOSE Losartan, an angiotensin II receptor blocker, can reduce desmoplasia and enhance drug delivery and efficacy through improving interstitial transport and vascular perfusion in pancreatic ductal adenocarcinoma (PDAC) models in mice. The purpose of this study was to determine whether magnetic resonance imaging (MRI) of magnetic iron oxide nanoparticles (MNPs) and micro-positron emission to...

Primary or acquired resistance of tumours to established chemotherapeutic regimens is a major concern in oncology. Attempts to improve the survival of cancer patients largely depend on strategies to prevent tumour cell resistance. 5-Fluorouracil (5-FU)-based chemotherapy with a combination of other drugs such as irinotecan (IRT) and oxaliplatin (OXT) has been reported to be effective, even thou...

Naproxen (Nap), a non-steroidal anti-inflammatory drug, and 5-fluorouracil (5FU), an anticancer were easily incorporated into polyurea xerogel. Polyureas (PUr) synthesized by one pot reaction via sol–gel chemistry. Soft segments based on polyetheramine-PEO hard hexamethylene diisocyanate trimer (HDI). The final materials characterized Fourier transform infrared (FTIR) spectroscopy, small-angle ...