In an observational cohort study, we found that adults hospitalized for oseltamivir-resistant (H275Y) seasonal H1N1 influenza (n = 46) were older than those infected with oseltamivir-susceptible strains (n = 31) [74(IQR 59-83) versus 64(IQR 48-76) years; P = 0·045], and most had major comorbidities (78% versus 65%). Disease severity and clinical outcomes were comparable between the two groups: ...

In the current study, interstitial fluid (ISF), bradykinin (BK), and angiotensin II (ANG II) levels were measured using cardiac microdialysis in conscious, nonsedated rats at baseline and at 48 h and 5 days after each of the following: sham surgery (sham, n = 6), sham + administration of ANG-converting enzyme inhibitor ramipril (R, n = 6), creation of aortocaval fistula (ACF, n = 6), ACF + R (n...

Performance of a pilot Biofiltration system in removing of Triethylamine (TEA) vapor from air stream was evaluated in this study. Experiments were conducted with two 6-L three section biofilters containing a mixture of compost (60%) and wood chips (40%). The systems were operated at 20±2 and 30±1 ?C. Municipal activated sludge was added initially to promote microbial growth and the systems were...

Megakaryocytopoiesis in the spleens of lethally irradiated mice transplanted with marrow cells was suppressed by platelet transfusions. In one group of experiments, animals were irradiated and transfused with bone marrow cells on day O. They were then given either no treatment, platelets, platelet-poor plasma, or saline on days 0, 2, 4, 6, and 8, and then were sacrificed on day 10. Megakaryocyt...

introduction: today, investigators pay attention to natural fluids (such as follicular and amniotic fluid) to use them as a medium or a supplement. using human amniotic fluid (haf) in some researches, not only improved in vitro development of preimplantation embryos but also significantly increased percentage of pregnancy. on the contrary, gianaroli et al. have claimed there was no significant ...

Methods B16F10-OVA melanoma bearing C57BL/6 mice were immunized with the lentiviral vector DCVex on 10 days after tumor challenge to induce OVA specific effector and memory CD8 T cells. Mice were then treated 12 days later intratumorally with the TLR4 agonist GLAAS (glucopyranosyl adjuvant system), which induces the T cell homing chemokines CXCL9 and CXCL10. Control mice received no treatment o...

Twenty-one patients with recurrent or progressive glioblastoma were enrolled in a prospective phase II trial to determine the safety and efficacy of a 1-week on/1-week off regimen of temozolomide administered at 150 mg/m2 on days 1 to 7 and days 15 to 21 of 28-day treatment cycles. Two patients achieved a partial response (10%), and 17 patients (81%) had stable disease. The median progression-f...

Skeletal muscle catabolism is a characteristic metabolic response to sepsis. We investigated the ability of physiological insulin (2 nM) or insulin-like growth factor I (IGF-I, 10 nM) concentrations to modify protein metabolism during incubation of epitrochlearis 2, 6, or 15 days after injection of live Escherichia coli. On days 2 and 6 postinfection, skeletal muscle exhibited an exacerbated ne...

We gave 21 healthy young men 100 mg of hydrochlorothiazide daily to determine whether or not urinary detection of the drug was feasible as a measure of compliance on a standard antihypertensive regimen. All subjects took the drug daily for 6 days, after which they were divided into four groups with differing patterns of medication administration. Urine hydrochlorothiazide and creatinine measure...

Abstract Helminths are parasitic worm pathogens known to induce innate acquired type 2 immune responses that lead the accumulation of granulocytes in peripheral tissues. N. brasiliensis is a natural rat nematode parasite used mouse models elicit this response. Infective larvae injected into skin, migrate lung within 24–48 hours, coughed up at 48–72 and mature intestines 5–6 days. Though much ab...