Biologics have transformed the management of moderate-to-severe psoriasis; however, none are curative, and an increasing number patients failed all available classes. MSCs, multipotent stem cells with immunomodulatory properties been used to treat immune-mediated inflammatory diseases including rheumatoid arthritis Crohn disease. We investigated efficacy safety umbilical cord-derived MSCs in 2 ...

1. Tambourgi DV, Morgan BP, De Andrade RMG, et al. Loxosceles intermedia spider envenomation induces activation of an endogenous metalloproteinase, resulting in cleavage of glycophorins from the erythrocyte surface and facilitating complement-mediated lysis. Blood. 2000;95:683-691. 2. Wasserman GS, Anderson PC. Loxoscelism and necrotic arachnidism. J Toxicol Clin Toxicol. 1983-1984;21:451-472. ...

We introduce a lattice fermion-Higgs model with one component ‘reduced staggered’ fermions. In order to use the fermion field as efficiently as possible we couple the two staggered flavors to the O(4) Higgs field leading to a model with only one SU(2) doublet in the scaling region. The number of fermions is doubled in a numerical investigation of the model with the hybrid Monte Carlo algorithm....

The robustness of the control strategies developed in the COST 624 benchmark have been tested against the sophistication of the model describing the hydraulic behaviour of the biological reactor of a wastewater treatment plant by activated sludge. In such a large biological reactor of the channel type, hydrodynamics are intermediate between plug flow and well-mixed and are function of the liqui...

If f is an endomorphism of a finite dimensional vector space over a field K then an invariant subspace X ⊆ V is called hyperinvariant (respectively, characteristic) if X is invariant under all endomorphisms (respectively, automorphisms) that commute with f . According to Shoda (Math. Zeit. 31, 611–624, 1930) only if |K| = 2 then there exist endomorphisms f with invariant subspaces that are char...

1. Papergeorgiou EA, Karagrigoriou A, Tsaliki E, Velissariou V, Carter NP, Patsalis PC. Fetal-specific DNA methylation ratio permits noninvasive prenatal diagnosis of trisomy 21. Nature Med 2011: 17: 510–513. 2. Society of Obstetricians and Gynaecologists of Canada. Canadian Guidelines for Prenatal Diagnosis. J Obstet Gynaecol Can 2001: 23: 616–624. 3. Rakyan VK, Down TA, Thorne NP et al. An in...

BACKGROUND The objective of this study was to explore the correlates of ever had sex among perinatally HIV-infected (PHIV) adolescents. METHODS A cross-sectional survey of sexual behaviour was conducted with 624 PHIV adolescents living three regions (12 districts) of Uganda. Data was collected on socio demographic characteristics (age, sex, occupation, religion and education status), sexual p...