Abstract Background Cefiderocol is a novel cephalosporin that binds to ferric acid and moved across the outer membrane of Gram-negative bacilli via iron transport. Once through membrane, cefiderocol able exert typical activity. Because its ‘Trojan horse’-like mechanism action, elude bacterial resistance mechanisms has activity against multidrug-resistant organisms (MDROs), including Acinetobact...

High Q-factors are of utmost importance to minimize losses superconducting radio-frequency cavities deployed in continuous wave particle accelerators. This study elucidates the surface treatment that can maximize high-beta 650 MHz elliptical niobium cavities. State-of-the-art treatments applied many single-cell cavities, and resistance studies performed understand microwave dissipation at this ...

In a novel approach in observational highenergy gamma-ray astronomy, observations carried out by imaging atmospheric Cherenkov telescopes provide necessary templates to pinpoint the nature of intriguing, yet unidentified EGRET gamma-ray sources. Using GeV-photons detected by CGRO EGRET and taking advantage of high spatial resolution images from H.E.S.S. observations, we were able to shed new li...

CREB (cAMP Response Element Binding protein) is a transcription factor that is overexpressed in primary acute myeloid leukemia (AML) cells and associated with a decreased event-free survival and increased risk of relapse. We recently reported a small molecule inhibitor of CREB, XX-650-23, which inhibits CREB activity in AML cells. Structure-activity relationship analysis for chemical compounds ...

OBJECTIVES To compare within the same individuals two typically prescribed doses of hydrocodone/acetaminophen and oxycodone/acetaminophen products for their subjective, psychomotor, and physiological effects in healthy volunteers. DESIGN A randomized, placebo-controlled, double-blind, crossover, six-session clinical laboratory study, enrolling 16 healthy participants (27.2 +/- 4.4 years of ag...