Abstract Introduction The Insomnia Severity Index (ISI) is a 7-item self-reported questionnaire evaluating perception of symptom severity included in Phase 3 studies lemborexant (LEM), competitive dual orexin receptor antagonist approved several countries to treat adults with insomnia. ISI total score, and items 4-7 for daytime function (DF), improved significantly LEM treatment compared placeb...

Quantitative analyses were performed on computer tomography (CT) scans from 7 patients with Korsakoff’s syndrome, 7 age-matched alcoholic subjects, and 7 age-matched healthy control subjects. CT values were used to estimate tissue density and fluid volume in specified brain areas. Tissue density was assessed by averaging CT values in small (5 x 5 mm) areas sampled bilaterally in 6 specified are...

The aim of this study is to describe the ability identify scientific publications through technological literacy including, access articles, select and develop articles that have 76 class PGSD, 2018. This kind a action study. data collection used questionnaire for while documentation techniques compile article so, analysis USES quantitative descriptive technique. Research shows that, before Ind...

Background: Strain-specific antibodies to human cytomegalovirus (HCMV) glycoproteins B and H (gB gH) have been proposed as a potential diagnostic tool for identifying reinfection. We investigated genotype-specific IgG antibody responses in parallel with defining the gB gH genotypes of infecting viral strains. Methods: Subjects primary (n = 20) or non-primary 25) HCMV infection were studied. The...

Background: The tongue is one of the most important organs in oral cavity, and its lesions are a health concern for healthcare providers patients. Limited epidemiological studies have evaluated children. present study aimed to evaluate prevalence various on population Iranian students. Methods: A total 2051 students, aged 7–12 years, were randomly selected from elementary schools Kerman using r...

Testosterone (250 microM), 7-ethoxycoumarin (25 microM), and 1-chloro-2,4-dinitrobenzene (CDNB, 50 microM) were used as substrates to compare phase I and II metabolism in rat precision-cut liver slices and rat hepatocytes. Overall clearance to metabolites was significantly greater in hepatocytes for testosterone (1.9- to 16.9-fold), 7-ethoxycoumarin (O-deethylation, 14.8-fold; glucuronidation, ...

The aim of the present study was to evaluate the frequency of detection of Mogibacterium timidum in subgingival samples of subjects with generalized aggressive periodontitis (GAgP) and uncontrolled diabetic and non-diabetic subjects with generalized chronic periodontitis (GChP). 48 patients with GAgP, 50 non-diabetic and 39 uncontrolled (glycated hemoglobin >7%) type 2 diabetic subjects with GC...

Using real-time quantitative PCR, cell-free EBV DNA was detectable in the plasma of 96% (55 of 57) of nasopharyngeal carcinoma (NPC) patients (median concentration, 21058 copies/ml) and 7% (3 of 43) of controls (median concentration, 0 copies/ml). Advanced-stage NPC patients had higher plasma EBV DNA levels than those with early-stage disease. At 1 month after completion of radiotherapy, plasma...

Gustatory differences in Phenylthiocarbamide (PTC) tasters and non-tasters were studied in hypothyroid and hyperthyroid subjects. After presenting for PTC sensitivity, gustatory responses to 7 dilutions of test solutions for glucose (sweet), sodium chloride (salt), citric acid (sour) and quinine sulphate (bitter) were studied in PTC tasters and non-tasters. The intensity and pleasantness respon...

Using real-time quantitative PCR, cell-free EBV DNA was detectable in the plasma of 96% (55 of 57) of nasopharyngeal carcinoma (NPC) patients (median concentration, 21058 copies/ml) and 7% (3 of 43) of controls (median concentration, 0 copies/ml). Advanced-stage NPC patients had higher plasma EBV DNA levels than those with early-stage disease. At 1 month after completion of radiotherapy, plasma...