Computational anatomy methods are now widely used in clinical neuroimaging to map the profile of disease effects on the brain and its clinical correlates. In Alzheimer's disease (AD), many research groups have modeled localized changes in hippocampal and lateral ventricular surfaces, to provide candidate biomarkers of disease progression for drug trials. We combined the power of parametric surf...

OBJECTIVE To examine the attitude of patients towards generic drugs and prescriptions containing generic drugs as an alternative to brand-name products, with a special focus on information on patients attitude to generic drugs provided by their general practitioners (GPs). METHODS A total of 804 patients in 31 general practices were surveyed using a self-questionnaire. The influence of age, s...

This paper describes the development of a linear lumped-parameter hand/arm model for the operator of a telemanipulation system. The authors previously developed a control architecture that implements frequency-domain loop-shaping compensators to improve the transparency or ‘‘feel’’ of a telemanipulation system, and a human model is used when simulating this architecture. Typically, the human is...

The present two studies with a 3-year longitudinal design examined the co-development of science, math, and language (e.g., Spanish/Finnish) interest among 1,317 Spanish 804 Finnish secondary school students across their transition to post-compulsory education, taking into account role gender, performance, socioeconomic status (SES). research questions were analyzed parallel process latent grow...

We present a linear programming-based method for finding “gadgets,” i.e., combinatorial structures reducing constraints of one optimization problem to constraints of another. A key step in this method is a simple observation which limits the search space to a finite one. Using this new method we present a number of new, computer-constructed gadgets for several different reductions. This method ...

The structural determinants of aldosterone binding specificity in the mineralocorticoid receptor (MR) have not been determined. The MR has greatest sequence identity with the better characterized glucocorticoid receptor (GR), which is reflected in their overlapping ligand binding specificities. There must be subtle sequence differences that can account for the MR-specific binding of aldosterone...