BACKGROUND Although the positive relationship between insulin resistance (IR) and central obesity is well known, the direct relationship between waist circumference and IR is not clear yet and there is no consensus regarding the cut off value for waist circumference as a surrogate index for central obesity. The present study was aimed to determine the optimal cut-off value of waist circumferenc...

OBJECTIVE To evaluate the impact of comparative performance feedback to community pharmacists on provision of professional services and the quality of patients' medication use. DESIGN Randomised, controlled, single-blind trial. SETTING All 1833 community pharmacies in the Quebec province, Canada. PARTICIPANTS 1814 pharmacies not opting out and with more than 5 dispensings of the target me...

BACKGROUND Rapid tests are now widely available to assist the diagnosis of influenza; implementation may optimise the use of antiviral and antibiotic agents in the clinical management of influenza. OBJECTIVE To explore the clinical management of children with influenza-like illness (ILI) when rapid influenza tests were and were not performed. METHODS Between 15 January 2007 and 30 April 200...

Abstract Aim End-stage ankle arthritis poses numerous healthcare challenges, not least given its high prevalence but also significant limitations in treatment modality. This study compares functional outcomes following total arthroplasty (TAR) versus arthroscopic arthrodesis (AAA). Secondary objectives were to compare complication rates and perform a health economic analysis estimate cost-effec...

P-glycoprotein is an energy-dependent drug efflux pump with broad specificity for hydrophobic antitumor agents such as vinblastine, doxorubicin, and taxol. We have previously shown that [3H]azidopine and [125I] iodoaryl azidoprazosin, which are photoaffinity probes for the alpha 1-subunit of the L-type calcium channel and alpha 1-adrenergic receptor, respectively, specifically interact with P-g...

In this article we are interested in quantitative homogenization results for linear elliptic equations the nonstationary situation of a straight interface between two heterogeneous media. This extends previous work [M. Josien, Comm. Partial Differential Equations, 14 (2019), pp. 907--939] to substantially more general setting, which surrounding media may be periodic or random stationary and erg...

Abstract Humans in most cultures around the world play rule-based games, yet research on content and structure of these games is limited. Previous studies investigating across have either focused a small handful cultures, thus limiting generalizability findings, or used cross-cultural databases from which raw data are not accessible, transparency, applicability, replicability findings. Furtherm...