Recent studies have demonstrated the high selectivity of neurons in primary auditory cortex (A1) and a highly sparse representation of sounds by the population of A1 neurons in awake animals. However, the underlying receptive field structures that confer high selectivity on A1 neurons are poorly understood. The sharp tuning of A1 neurons' excitatory receptive fields (RFs) provides a partial exp...

ion monitoring information (possible bindings of variables) Solution a1 = A1 t1 = 10 t2 = t1 + 20 investigate−area(a1, t1) ... Root HSN Soft constraints problem model

6,324,532 B1* 11/2001 Spence et a1. ................. .. 706/27 6,901,167 B2 5/2005 Herley 7,286,707 B2 10/2007 Liu et a1. 7,702,596 B2 4/2010 Tu et a1. 7,848,566 B2 * 12/2010 Schneiderman ............ .. 382/159 8,092,388 B2 * 1/2012 Park et a1. ................... .. 600/45

■ ■ Excellent linearity, accuracy, and precision INTRODUCTION Apolipoprotein A1 (Apo A1) protein is a major component of High Density Lipoprotein (HDL) in plasma. Along with other lipoproteins, Apo A1 plays a key role in lipid metabolism.1 While typical levels of Apo A1 are >1.2 mg/mL for males and >1.4 mg/mL for females,2 reduced plasma concentrations of Apo A1 have been reported in patients a...

a1-Microglobulin is a 26-kd protein, widespread in plasma and tissues and wellconserved among vertebrates. a1-Microglobulin belongs to the lipocalins, a protein superfamily with highly conserved 3-dimensional structures, forming an internal ligand binding pocket. The protein, isolated from urine, has a heterogeneous yellow-brown chromophore bound covalently to amino acid side groups around the ...

Excessive mitochondrial fission is associated with the pathogenesis of neurodegenerative diseases. Dynamin-related protein 1 (Drp1) possesses specific fission activity in the mitochondria and peroxisomes. Various post-translational modifications of Drp1 are known to modulate complex mitochondrial dynamics. However, the post-transcriptional regulation of Drp1 remains poorly understood. Here, we ...

Myelopoiesis is under the control of a complex network containing various regulation factors. Deregulation of any important regulation factors may result in serious consequences including acute myeloid leukemia (AML). In order to find out the genes that may take a part in AML development, we analyzed data from AML cDNA microarray (GSE2191) in the NCBI data pool and noticed that heterogeneous nu...

Nasopharyngeal carcinoma (NPC) has a highly increased incidence rate (20/100,000) in Southern regions of China, while being rare in the rest of the world. NPC is a malignant type of cancer due to its high occurrence rate of metastasis; however, biomarkers for effective diagnosis and treatment are yet to be identified. Annexin A1 is a glucocorticoid‑regulated member of a large superfamily of cal...