The study reported in the present issue of the Journal of Alzheimer’s disease by Mizoroki et al. [8] concludes that the failure of treatment of transgenic mice with aluminum maltolate to induce Alzheimer’s-like neuropathological changes provides proof that aluminum is not a causative agent in the etiology of Alzheimer’s disease. In our opinion, this report by Mizoroki et al. fails to provide an...

: In this work, we have proposed a concept for the generation of three-dimensional (3D) nanostructured metal alloys of immiscible materials induced by megahertz-frequency ultrafast laser pulses. A mixture of two microparticle materials (aluminum and nickel oxide) and nickel oxide microparticles coated onto an aluminum foil have been used in this study. After laser irradiation, three different t...

Although chronic aluminum neurotoxicity has been well established, the mechanism of the toxicity has not been elucidated yet. In order to simplify the study of the aluminum neurotoxicity, we employed the pulse exposure of cultured rat cortical neurons to 250 microM aluminum-maltol for 1 h at the early stage (6 h after plating), which resulted in abnormal distribution of neurofilament L (NFL) an...

Anemia has been associated with aluminum intoxication in patients on chronic dialysis and in animals. In studies presented here, in vitro human erythroid culture was used to delineate the effects of aluminum on normal hematopoiesis. Aluminum by itself in routine culture, even at very high levels (1,035 ng/ml), did not significantly affect erythroid colony growth. The addition of human transferr...

This paper describes synthesis of ultrathin pinhole-free insulating aluminum oxide layers for electronic device protection in corrosive liquid environments, such as phosphate buffered saline (PBS) or clinical fluids, to enable emerging biomedical applications such as biomolecular sensors. A pinhole-free 25-nm thick amorphous aluminum oxide layer has been achieved using ultra-high vacuum DC magn...

We have examined the neurotoxicity of aluminum in humans and animals under various conditions, following different routes of administration, and provide an overview of the various associated disease states. The literature demonstrates clearly negative impacts of aluminum on the nervous system across the age span. In adults, aluminum exposure can lead to apparently age-related neurological defic...

The effects of aluminum implantation on HfO2 thin films using plasma immersion ion implantation (Al– PIII samples) are investigated. X-ray photoelectron spectroscopy measurements reveal that most of the implanted aluminum atoms accumulated near the surface region of the oxide film. The greatly reduced leakage current, smaller flatband shift and steep transition from the accumulation to the depl...

The objectives in this study were to deterrnine the through-thickness elastic constant of fiber-epoxy/metal composites with ultrasonic measurements and determine the elastic constants of the constituent layers. The specimens that we studied consist of alternaring layers of aluminum (2024 TI) and fiber-epoxy [1], all of which are 200 to 300 jlm thick. As Figure 1 indicates the outer two layers o...

fiber metal laminates are hybrid laminates consisting of thin alternating bonded layers of aluminum and fiber/epoxy. arall (aramid aluminum laminate) and galare (glass fiber reinforced aluminum laminate) are specific kinds of fiber metal laminates that consist of thin aluminum sheets along with kevlar/epoxy and glass/epoxy composite layers, respectively. in this study, nonlinear tensile behavio...