نتایج جستجو برای: abscission

تعداد نتایج: 1629  

2013
Matthew K. Martz Elda Grabocka Neil Beeharry Timothy J. Yen Philip B. Wedegaertner

Proper completion of mitosis requires the concerted effort of multiple RhoGEFs. Here we show that leukemia-associated RhoGEF (LARG), a RhoA-specific RGS-RhoGEF, is required for abscission, the final stage of cytokinesis, in which the intercellular membrane is cleaved between daughter cells. LARG colocalizes with α-tubulin at the spindle poles before localizing to the central spindle. During cyt...

Journal: :Journal of experimental botany 2005
Eric John Belfield Benedetto Ruperti Jeremy Alan Roberts Simon McQueen-Mason

During ethylene-promoted leaflet abscission in Sambucus nigra a 7-fold increase in expansin activity was detected specifically in tissues undergoing cell separation, whilst only low levels of activity were seen in adjacent non-abscising tissues. An RT-PCR strategy was used to amplify expansin fragments from a cDNA library generated from mRNA extracted from ethylene-treated leaflet abscission-zo...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Hee Jung Kim Jungbin Yoon Atsushi Matsuura Jung-Hyun Na Won-Kyu Lee Hyunook Kim Ji Woong Choi Ji Eun Park Sung-Jean Park Kyung Tae Kim Rakwoo Chang Byung Il Lee Yeon Gyu Yu Yeon-Kyun Shin Cherlhyun Jeong Kunsoo Rhee Hyung Ho Lee

Intercellular bridges are a conserved feature of spermatogenesis in mammalian germ cells and derive from arresting cell abscission at the final stage of cytokinesis. However, it remains to be fully understood how germ cell abscission is arrested in the presence of general cytokinesis components. The TEX14 (testis-expressed gene 14) protein is recruited to the midbody and plays a key role in the...

Journal: :Plant physiology 1973
B W Poovaiah

Peroxidase activity and localization in the abscission zone of bean leaves were studied histochemically and by gel electrophoresis. Deblading of bean leaves resulted in an increase in peroxidase activity in the abscission zone 2 to 4 days after deblading with highest activity just prior to separation. In debladed plants, the cell division in six to eight layers of cells preceded separation. An ...

Journal: :Plant physiology 1963
L A Rosen S M Siegel

' Received Sept. 27, 1962. ing 125 mm being miiade up with either argon or ethylene. The followiing gas mixtures were used: air, 10 % 02 + 90% A, 7.5% O., + 92.5 % A, 5% 02 + 95% A. In other experimlenits the partial pressure of ethylene in the jars was varied from 0 to 253 nim Hg, while the O. level was maintained at 5 % and total pressure adjusted to 760 mim with argon. For comparative purpos...

Journal: :Cell 2009
Patrick Steigemann Claudia Wurzenberger Michael H.A. Schmitz Michael Held Julien Guizetti Sandra Maar Daniel W. Gerlich

Genomic abnormalities are often seen in tumor cells, and tetraploidization, which results from failures during cytokinesis, is presumed to be an early step in cancer formation. Here, we report a cell division control mechanism that prevents tetraploidization in human cells with perturbed chromosome segregation. First, we found that Aurora B inactivation promotes completion of cytokinesis by abs...

2012
Mar Carmena

At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges 'stuck' in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, triggering a checkpoint that delays abscission until the chromatin bridges have been resolved. Rec...

2013
Jorge Corbacho Félix Romojaro Jean-Claude Pech Alain Latché Maria C. Gomez-Jimenez

BACKGROUND Mature-fruit abscission (MFA) in fleshy-fruit is a genetically controlled process with mechanisms that, contrary to immature-fruit abscission, has not been fully characterized. Here, we use pyrosequencing to characterize the transcriptomes of melon abscission zone (AZ) at three stages during AZ-cell separation in order to understand MFA control at an early stage of AZ-activation. P...

2017
Julia König E B Frankel Anjon Audhya Thomas Müller-Reichert

Abscission is the final step of cytokinesis and results in the physical separation of two daughter cells. In this study, we conducted a time-resolved series of electron tomographic reconstructions to define the steps required for the first embryonic abscission in Caenorhabditis elegans Our findings indicate that membrane scission occurs on both sides of the midbody ring with random order and th...

Journal: :The Journal of biological chemistry 2006
Xiao-Wei Chen Mayumi Inoue Shu C Hsu Alan R Saltiel

In eukaryotic cells, recycling endosome-mediated trafficking contributes to the completion of cytokinesis, in a manner under the control of the centrosome. We report that the exocyst complex and its interacting GTPase RalA play a critical role in this polarized trafficking process. RalA resides in the recycling endosome and relocates from the pericentrosomal region to key cytokinetic structures...

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