α-Glucosidase inhibition is considered as an effective strategy for the treatment of diabetes mellitus. Currently, three α-glucosidase inhibitors are being used drugs; Acarbose, Voglibose and Miglitol. The side effects these drugs forcing researchers to search new molecules. In this research work, novel 1,2,3-benzotriazin-4(3H)-one sulfonamides were synthesized investigated their activity. 2,4,...

Many diseases in nature have led to the death of many young and old. bacteria developed resistance available antibiotics on market. And drugs employed treating such as diabetes mellitus are expensive not locally available. Therefore, order search for more effective, inexpensive, drugs, this study synthesized investigated biological activities Andrographis paniculata crude extract its Co (II) Ni...

BACKGROUND Although numerous clinical trials have evaluated the body weight change achieved using diabetes medications alone or in combinations, the composition of body weight change in these clinical trials has rarely been assessed. OBJECTIVE We aimed to evaluate the effects of gliclazide, metformin, and acarbose monotherapy on body composition, fat distribution, and other cardiometabolic ri...

BACKGROUND AND OBJECTIVES In this study we examined the effects of switching α-glucosidase inhibitors (α-GI) from acarbose or voglibose to miglitol on glucose fluctuations and circulating concentrations of cardiovascular disease risk factors, such as soluble adhesion molecules (sE-selectin, sICAM-1 and sVCAM-1), a chemokine monocyte chemoattractant protein (MCP)-1, plasminogen activator inhibit...

Objective: The present study was planned to explore phytoconstituents and hypoglycemic potential of the leaf extracts of Acanthus ilicifolius and Evolvulus emerginatus by invitro method. Methods: The aqueous, ethanol and methanol leaf extracts were prepared by soxhlation method. Qualitative phytochemical screening was done by using Horborne method. Methanol leaf extracts and standard drug acarb...

The inhibitory activity on pancreatic α-amylase by cyanidin-3-rutinoside was examined in vitro. The IC₅₀ value of cyanidin-3-rutinoside against pancreatic α-amylase was 24.4 ± 0.1 μM. The kinetic analysis revealed that pancreatic α-amylase was inhibited by cyanidin-3-rutinoside in a non-competitive manner. The additive inhibition of a combination of cyanidin-3-rutinoside with acarbose against p...

A novel series of 2-substituted-4,6-diarylpyrimidines 6a-6t has been synthesized, characterized by ¹H-NMR, 13C-NMR and HRMS, and screened for in vitro α-glucosidase inhibitory activity. The majority of the screened compounds possessed significant α-glucosidase inhibitory activity with IC50 values ranging from 19.6 ± 0.21 to 38.9 ± 0.35 μM, which is more potent than the positive control α-glucos...

Pneumatosis cystoides intestinalis is a rare disorder with multiple submucosal or subserosal gas-filled cysts along the gastrointestinal wall. Pneumatosis intestinalis can be classified as either primary (idiopathic) or secondary. In the latter form, a causal relationship has been established with chronic obstructive pulmonary disease, amyloidosis, infectious colitis, intestinal obstruction, is...

Garlic (Allium sativum L., Alliaceae), Persian shallot (Allium ascalonicum L., Alliaceae ) and Sage (Salvia officinalis L., Lamiaceae) are believed to have hypoglycemic properties and have been used traditionally as antidiabetic herbal medicines in Iran. In this study, diabetes was induced by subcutaneous injection of alloxan monohydrate (100 mg kg−1) to male Wistar rats. Antidiabetic effects of...