BACKGROUND Using human skin-fibroblast cell line HF2FF, the efficacy of some drugs was evaluated against sulfur mustard (SM) cytotoxicity. The drugs were the sulfhydryl containing molecule including N-acetylcysteine (NAC), 2-oxo-thiazolidine-4-carboxylate (OTC) and acetaminophen as glutathione (GSH) stimulator pathway. METHODS The protective effects of NAC (0.1 mM), OTC (1.8 mM), and acetamin...

Acetaminophen (paracetamol, N-acetyl-p-aminophenol) is an effective, mild analgesic, antipyretic agent and is probably the most widely used of all drugs in the world. It does not share the formidable prostaglandin-dependent toxicity of aspirin and other conventional nonsteroidal anti-inflammatory agents, and when used properly, it has an excellent safety record. In many countries, it is fashion...

1. Manage a suspected acetaminophen overdose. 2. Describe one of the metabolic effects of ethanol ingestion in young children. 3. Delineate the signs and symptoms of theophylline toxicity. 4. Determine the cardiac anomaly that may be associated with an overdose of tricyclic antidepressants and how to assess the risk. 5. Manage a child who has ingested a hydrocarbon substance. 6. Recognize the s...