Nutritional interventions have shown varied efficacy on cognitive performance during Alzheimer's disease (AD). Twenty-four individuals diagnosed with AD received a nutraceutical formulation (NF: folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) under open-label conditions (ClinicalTrials.gov NCT01320527). Primary outcome was cognitive performance. Sec...

Thirty-four individuals with mild cognitive impairment were randomized for 6 months to a nutraceutical formulation (NF: folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) or indistinguishable placebo, followed by a 6-month open-label extension in which all individuals received NF. The NF cohort improved in the Dementia Rating Scale (DRS; effect size >0...

Some time ago we demonstrated the acetylation of S-benzyl-L-cysteine in the dog, rabbit, rat, and man (l-3). Administration of S-benzyl-ncysteine to rats (4, 5) or man (3) was followed by the excretion of some N-acetyl-S-benzyl-L-cysteine, thus indicating a partial inversion of the D derivative of cysteine to the optical antipode. Ample experimental evidence is available to show that oxidative ...

pyrene and tran8-4,5-dihydro-4,5-dihydroxypyrene, were present in the bile of rats treated with pyrene. 3. In the oxidation of pyrene with perbenzoic acid an intermediate was formed, believed to be 4,5-epoxy-4,5-dihydropyrene, which reacted with water to yield tran8-4,5-dihydro-4,5-dihydroxypyrene and with N-acetyl-L-cysteine to form Nacetyl-S-(4,5-dihydro-4-hydroxy-5-pyrenyl)-L-CySteine. 1-Hyd...