Backgrounds: Genetic alterations are strongly involved in carcinogenesis and pathogenesis of melanoma. Although non-acral cutaneous melanoma has been fully analyzed, acral mucosal need more investigation. Somatic copy number variation (CNV) is one the major genetic melanomas. Previous studies have suggested that CNV due to instability caused early palmoplantar melanoma, however it not yet evalu...

Vol. 26 No. 1, 2014 123 Received July 20, 2012, Revised January 25, 2013, Accepted for publication March 12, 2013 Corresponding author: Dong-Youn Lee, Department of Dermatology, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea. Tel: 82-2-3410-3543, Fax: 82-2-3410-3869, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creative Commons ...

Superficial acral fibromyxoma (SAFM) is a rare myxoid tumor that was first described in 2001. The presence of a very slow growing solitary tender mass in the subungual area is the typical clinical feature at presentation. Histopathologically, SAFM is composed of stellate cells in a myxocollagenous matrix with a poorly circumscribed margin. This tumor is thought to be benign, but its natural cou...

Acro-lentiginous melanoma, a pigmented lesion of the extremities, especially palms and soles, is defined by malignant tumor proliferation with high metastatic potential, which develops at expense melanocytes. Its incidence constantly increasing varies according to country ethnicity. diagnosis primarily histopathological, its management remains multidisciplinary, where surgery plastic surgeon oc...