OBJECTIVES In a computed tomographic (CT) angiography study, we identified the characteristics of atherosclerotic lesions that were associated with subsequent development of acute coronary syndrome (ACS). BACKGROUND The CT characteristics of culprit lesions in ACS include positive vessel remodeling (PR) and low-attenuation plaques (LAP). These 2 features have been observed in the lesions that...

BACKGROUND Previous research suggests that the presentation of acute coronary syndromes (ACS) may differ in women and men. No study has prospectively evaluated the role of a comprehensive set of typical and atypical symptoms and whether different symptoms on presentation predict ACS diagnosis in women and men. METHODS AND RESULTS We directly observed 246 women and 276 men seen in the emergenc...

The past decade has seen a significant interest in learning tractable probabilistic representations. Arithmetic circuits (ACs) were among the first proposed tractable representations, with some subsequent representations being instances of ACs with weaker or stronger properties. In this paper, we provide a formal basis under which variants on ACs can be compared, and where the precise roles and...

This paper introduces ant colony system (ACS), a distributed algorithm that is applied to the traveling salesman problem (TSP). In ACS, a set of cooperating agents called ants cooperate to find good solutions to TSPs. Ants cooperate using an indirect form of communication mediated by pheromone they deposit on the edges of the TSP graph while building solutions. We study ACS by running experimen...

The mechanisms underlying the increased risk of cardiovascular disease associated with diabetes mellitus (DM) are not fully defined. Insulin resistance in human metabolic syndrome patients is associated with decreased expression of the insulin receptor substrate-2- (Irs2-) AKT2 axis in mononuclear leukocytes (MLs). Moreover, acute coronary syndrome (ACS) has been linked through genome-wide asso...

The aim of this study is to compare the clinical characteristics of young women (<40 years) with older (≥40 years) admitted to the hospital emergency department with the diagnosis of acute coronary syndrome (ACS), and identify which cardiovascular risk factors are predictors to suffer an ACS in the group of young women. We included women consecutively admitted in a tertiary hospital with a diag...

Acute coronary syndrome (ACS) in patients with diabetes continues to present clinical management challenges despite recent improvements in the management of ACS. The diabetic myocardium is more vulnerable to ischemia–reperfusion injury than non-diabetic myocardium and the diabetic patient more likely to develop complications, significant morbidity and death following ACS. Currently, ACS managem...

Posttranslational regulation of protein function by acetylation is present throughout nature. Regulation of protein function by Sir2 protein (sirtuin) deacetylases is conserved in all domains of life. In the prokaryote Salmonella enterica, the metabolic enzyme acetyl-coenzyme A synthetase (Acs) is regulated by a Sir2-dependent protein acetylation/deacetylation system (SDPADS). The recent identi...

ACS Announcements ● Celebrate Earth Day 2006 with ACS Publications: "Dig into" selected research on soil and plant science from Environmental Science & Technology, the Journal of Agricultural and Food Chemistry, the Journal of Natural Products, and the Journal of Proteome Research. ● Most-Accessed Articles for ES&T in 2005. ● ES&T is #1 in total citations (34,474) and #1 in articles published (...