Voltage-gated potassium Kv1.2 channels play pivotal role in maintaining of resting membrane potential and, consequently, regulation of cellular excitability of neurons. Endogenously generated electric field (EF) have been proven as an important regulator for cell migration and tissue repair. The mechanisms of ion channel involvement in EF-induced cell responses are extensively studied but large...

Two highly interesting papers related to osteoclastic activation in multiple myeloma were published in the December 15 issue of Blood.1,2 These studies were related to the imbalance of 2 molecules involved in the regulation of bone resorption: receptor activator of NF-kappaB ligand (RANKL) and osteoprotegerin. Croucher and colleagues2 found that mouse myeloma cells expressed RANKL mRNA and that...

?-actinin-2 (?-actn-2) is an F-actin-crosslinking protein, localized in dendritic spines. In vitro studies suggested that it involved spinogenesis, morphogenesis, actin organization, cell migration and anchoring of the NR1 subunit N-methyl-D-aspartate (NMDA) receptors However, little known regarding its function vivo. We examined levels ?-actn-2 expression within dentate gyrus (DG) during devel...

BACKGROUND: Biosilica derived from Indonesian marine sponge Melophlus sarasinorum and Xestospongia testudinaria is one of the biomaterials that can be developed together with synthetic polymer as a composite. Poly E-caprolactone (PCL) used composite role an osteoconductive material biosilica also tailored slow rate degradation in body. This study aimed to create biocompatible biosilica-based sc...