Synaptic interactions between neurons of the human cerebral cortex were not directly studied to date. We recorded the first dataset, to our knowledge, on the synaptic effect of identified human pyramidal cells on various types of postsynaptic neurons and reveal complex events triggered by individual action potentials in the human neocortical network. Brain slices were prepared from nonpathologi...

background: the time and frequency features of motor unit action potentials (muaps) extracted from electromyographic (emg) signal provide discriminative information for diagnosis and treatment of neuromuscular disorders. however, the results of conventional automatic diagnosis methods using muap features is not convincing yet. objective: the main goal in designing a muap characterization system...

Specific patterns of neural impulses regulate genes controlling nervous system development and plasticity, but it is not known how intracellular signaling cascades and transcriptional activation mechanisms can regulate specific genes in response to specific patterns of action potentials. Studies using electrical stimulation of mouse dorsal root ganglion neurons in culture show that the temporal...

Specific patterns of neural impulses regulate genes controlling nervous system development and plasticity, but it is not known how intracellular signaling cascades and transcriptional activation mechanisms can regulate specific genes in response to specific patterns of action potentials. Studies using electrical stimulation of mouse dorsal root ganglion neurons in culture show that the temporal...

We examine the nature of the stationary character of the Hamilton action S for a space-time trajectory worldline x t of a single particle moving in one dimension with a general time-dependent potential energy function U x , t . We show that the action is a local minimum for sufficiently short worldlines for all potentials and for worldlines of any length in some potentials. For long enough worl...

The time course of the intracellular action potential was studied quantitatively, because it is an important factor in the generation of electromyographic signals. In in vivo preparations of the m. EDL and m. soleus of the rat single motor units were stimulated and intracellular action potentials were recorded in muscle fibres belonging to those motor units. In this arrangement it was possible ...

In order to explore the possibility of identifying toxins based on their effect on the shape of action potentials, we created a computer model of the action potential generation in NG108-15 cells (a neuroblastoma/glioma hybrid cell line). To generate the experimental data for model validation, voltage-dependent sodium, potassium and high-threshold calcium currents, as well as action potentials,...

Electrical properties of locust leg muscle fibers were studied by means of intracellular electrodes. In most fibers, a depolarizing current pulse initiated a local response. A delayed decrease in membrane resistance appeared with more than about 10 mv depolarization. In some fibers a regenerative response also was found. Membrane constants were measured, applying the short cable model. The valu...

Amat, Corine, Bruno Lapied, Andrew S. French, and Bernard guished by their ability to generate complex and long duraHue. Na-dependent neuritic spikes initiate Ca-dependent sotion action potentials. Intrasomatic recordings have shown matic plateau action potentials in insect dorsal paired median neuthat guinea pig inferior olivary neurons (Llinas and Yarom rons J. Neurophysiol. 80: 2718–2726, 19...

We studied the distribution and nature of the electrical changes associated with myocardial hypertrophy induced by renal hypertension in rats. Standard microelectrode techniques were used to study transmembrane action potentials recorded from endocardial, papillary muscle, and epicardial stimulation from hypertrophied (HBP) and normal (SHAM) hearts. We also determined the effects of stimulation...