A seven year old boy underwent routine tonsillectomy. The operation was complicated by catastrophic haemorrhage. The screening tests?Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) were normal. He was treated empirically with fresh frozen plasma but bleeding continued. Bilateral carotid ligation was ultimately required to arrest haemorrhage. He was subsequently referred t...

INTRODUCTION Ibuprofen is commonly used by Soldiers in the deployed environment. This study investigated its dose-effects on in vitro coagulation. METHODS Blood samples were collected from 4 normal healthy pigs and were processed to make platelet-adjusted (100×10(3)/μL) blood samples. Ibuprofen was added to the samples at doses of 0 μg/mL (control), recommended oral dose (163 μg/mL, 1×), 2×, ...

The coagulation cascade and inflammatory process are known to be associated with the pathophysiology of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). We retrospectively investigated laboratory values indicating coagulopathy obtained within 24 hr from diagnosis of ALI/ARDS in 79 children who received mechanical ventilation between 2008 and 2009 and their final outcomes....

the purpose of this research was to study the effect of one session of a progressive endurance running in two environments (natural temperature and moderate temperature) on some markers of the clotting system (fibrinogen, activated thromboplastin time or aptt, prothrombin time or pt) in active girls. 27 physical education female students from mazandaran university were selected and divided rand...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of disease 2019 (COVID-19) which associated with nonspecific syndromes, varying from mild symptoms upper airway to required mechanical ventilation hypoxemia. A unique feature this COVID-19-associated coagulopathy (CAC) that linked severity and hospital mortality. These patients have a profound hypercoagulable state in sev...

We evaluated the effect of sample volume and citrate concentration on results of routine coagulation assays (prothrombin time [PT] and activated partial thromboplastin time [APTT]). The study was performed on samples obtained from healthy persons and patients receiving oral anticoagulant therapy. Standard evacuated tubes (3.2% and 3.8% sodium citrate) were filled to varying total sample volumes...

The relationship between the antithrombotic and anticoagulant effects of heparin was assessed using venous thrombi in rabbits. Accretion of 125I-fibrinogen onto jugular vein thrombi was used to assess the antithrombotic effect of heparin, and the protamine sulfate titration test (heparin activity) and the activated partial thromboplastin time (APTT) were used to measure its anticoagulant effect...

To improve the safety of blood collection, plastic tubes have been developed but various interactions with the coagulation system and/or antithrombotic drugs were reported with the first generation of such tubes. The aim of this multicentre study was to compare hemostasis test results measured in evacuated plastic tubes made of polyethylene terephtalate (VenoSafe, Terumo Europe) and in siliconi...

In this paper, a microcantilever-based system enabling multiple coagulation tests on the same disposable cartridge is demonstrated. The system consists of independent cartridge and reader unit. The actuation of the nickel cantilevers is conducted remotely with an external electro-coil and remote optical read-out is utilized for sensing. Both Prothrombin Time (PT) and activated Partial Thrombopl...

obtained from the fermented intestine of Holothuria scabra (sand sea cucumber). Strain HSFI-5 had been reported to be able produce proteases, which shown several characteristics an antithrombotic agent, i.e., fibrinolytic and clot-lysis activities. However, its anticoagulation activity test is yest done. This study aimed determine anticoagulant crude protease in vitro. The design was a complete...