The fibrinolytic characteristics of the endothelial hybrid cell line EA.hy 926, established by fusing a human umbilical vein endothelial cell with a human carcinoma cell line, were studied. The hybrid cell line produced large amounts of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1, and a small amount of urokinase. All plasminogen activator present in conditio...

The effects of the reaction terms, diffusion coefficients and size of the computational domain on the dynamics of the two-equation Oregonator model in two-dimensional reactive–diffusive media is studied numerically, and it is shown that spiral waves are robust under truncation or expansion of the computational domain. It is also shown that large diffusion coefficients for the inhibitor may resu...

objective(s):to study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. materials and methods:forty new zealand rabbits were randomly divided into five groups with eight rabbits in each group. for each group, bone defects were generated in the left humerus of four rabbits, and in the right humerus of the other four rabbits. to t...

Mitogen-activated protein (MAP) kinase is a serine/threonine kinase whose function is thought to be essential for the transduction of mitogenic signals. MAP kinase is activated by phosphorylation induced by a variety of extracellular stimuli, and its direct upstream activator has been identified. Using amphibian and mammalian systems, we show here that ras can activate MAP kinase and its activa...

Antiserum against purified human urokinase was produced by immunization of Hartley strain guinea pigs. The antiserum was capable of neutralizing the plasminogen activator activity of the antigen and of native urokinase in human urine. The antiserum did not inhibit plasminogen activators of bacterial origin, i.e., streptokinase and staphylokinase; neither did it inhibit urokinase from nonprimate...

Abstract Geopolymer (GP) has recently emerged as a novel and environmental friendly alternative to conventional soil stabilization products like lime Ordinary Portland Cement (OPC), which adversely affect the environment. This article emphasizes GPs produced from high calcium class C fly ash (CFA) an alkali activator comprising sodium hydroxide silicate solution for sand stabilization. The expe...

This work investigates the effects of mixture parameters on slump flow and compressive strength a new type alkali-activated binder-based ultra-high concrete (AAB-UHSC) before after exposure to high temperatures. The innovative UHSC adopts combination sodium silicate (SS) potassium carbonate (PC) as activator. Compared with alkali hydroxide that is currently used in existing AAB-UHSC, salts are ...

Mutations in the BRCA1 gene are known to be a major cause of hereditary breast cancer. However, characterizing the point mutationsassociated with cancer in BRCA1 is challenging because the functional impact of most of them is still unknown. Nowadays, a variety of methods are employed to identify cancer-associated mutations in BRCA1. This study is aimed to ass...