Nitrogenase enzymes have evolved complex iron-sulfur (Fe-S) containing cofactors that most commonly contain molybdenum (MoFe, Nif) as a heterometal but also exist as vanadium (VFe, Vnf) and heterometal-independent (Fe-only, Anf) forms. All three varieties are capable of the reduction of dinitrogen (N(2)) to ammonia (NH(3)) but exhibit differences in catalytic rates and substrate specificity uni...

In this paper, the merger rate of black holes in a cluster primordial (PBHs) is investigated. The clusters have characteristics close to those typical globular star clusters. A that has wide mass spectrum ranging from 10−2 10M⊙ (Solar mass) and contains massive central hole M•=103M⊙ considered. It shown process evolution cluster, changed significantly, by now, PBH passed stage active merging in...

BACKGROUND Targeted interventions may be more effective at increasing children's physical activity. The aim of this study was to identify clusters of children based on physical activity and sedentary patterns across the week. METHODS Participants were 761, 10-11 year old children. Participant's self-reported time spent in eight physical activity and sedentary contexts and wore an acceleromete...

Traditionally, in IEEE 802.15.4 wireless sensor networks (WSN), cluster trees are constructed by connecting cluster heads. Though this way may reduce the number of routers, excess clusters may cause extra data transmission delay and will reduce the collection efficiency of sensing data. In this paper, we proposed a method that can effectively reduce the data transmission delay by minimizing the...

Efficient new codes enabling double electron-attachment equation-of-motion coupled-cluster (DEA-EOMCC) calculations with up to 4-particle–2-hole (4p-2h) excitations, treated active orbitals, h...

MOTIVATION To date, there is little knowledge about one of the processes fundamental to the biology of Plasmodium falciparum, gene regulation including transcriptional control. We use noisy threshold models to identify regulatory sequence elements explaining membership to a gene expression cluster where each cluster consists of genes active during the part of the developmental cycle inside a re...

Growth and usage trends for several large datasets indicate that there is a need for architectures that scale the processing power as the dataset increases. In this paper, we evaluate three architectural alternatives for rapidly growing and frequently reprocessed datasets: active disks, clusters, and shared memory multiprocessors (SMPs). The focus of this evaluation is to identify potential bot...

The interaction between nanoparticles and biomolecules such as protein andDNA is one of the major instructions of nanobiotechnology research. In this study,we have explored the interaction of adenine nucleic base with a representativegolden cluster (Au13) by using dispersion corrected density functional theory(DFT-D3) within GGA-PBE model of theory. Various active sites ...

The structure of A. thaliana imidazoleglycerol-phosphate dehydratase, an enzyme of histidine biosynthesis and a target for the triazole phosphonate herbicides, has been determined to 3.0 A resolution. The structure is composed of 24 identical subunits arranged in 432 symmetry and shows how the formation of a novel dimanganese cluster is crucial to the assembly of the active 24-mer from an inact...

Altered inositol metabolism is implicated in a number of diabetic complications. The first committed step in mammalian inositol catabolism is performed by myo-inositol oxygenase (MIOX), which catalyzes a unique four-electron dioxygen-dependent ring cleavage of myo-inositol to D-glucuronate. Here, we present the crystal structure of human MIOX in complex with myo-inosose-1 bound in a terminal mo...