in the present study, the toxic effects on the embryos and larvae of the turbot were used as a model to investigate the diazinon, which contaminates aquatic ecosystems. the number of dead embryos significantly increased in response to diazinon concentrations 0.2, 0.4, 0.8, 1.6, 3.2, and 7.4 mg/l. the 48h lc50 value of diazinon for turbot embryos was estimated at 1.85 mg/l. dose–response decrea...

in the present study, the toxic effects on the embryos and larvae of the turbot were used as a model to investigate the diazinon, which contaminates aquatic ecosystems. the number of dead embryos significantly increased in response to diazinon concentrations 0.2, 0.4, 0.8, 1.6, 3.2, and 7.4 mg/l. the 48h lc50 value of diazinon for turbot embryos was estimated at 1.85 mg/l. dose–response decreas...

The development of rapid methods for determining chronic toxicity parameters of chemical compounds introduced by the oral route into an organism with water was studied. Formulas are verified with which threshold values and no-effect toxicity doses for substances can be obtained on the basis of various toxicologic parameters. For the example of organophosphates, a methodological scheme was devel...

Galega officinalis (galega, Goat`s rue, French lilac) is a traditional plant from south east Europe. There are various reports about pharmacological properties of Galega officinalis such as diuretic, platelet aggregation, anti-bacterial, lactogen and anti-diabetic effect. There are a few studies about possible toxicological effect of this plant. In the present study, we evaluated the acute toxi...

Volans GN. The relationship between plasma ibuprofen concentrations and toxicity in acute ibuprofen overdose. Hum Toxicol 1988;7:319–24. 13 Court H, Volans GN. Poisoning after overdose with non-steroidal anti-inflammatory drugs. Adverse Drug React Acute Poisoning Rev 1984;3:1–21. 14 Temple AR. Acute and chronic effects of aspirin toxicity and their treatment. Arch Intern Med 1981;141(3 Spec No)...

Background: Fish have been at high risk of atrazine toxicity. Comparative atrazine toxicity on the tissues of Clarias gariepinus is scanty. Therefore, acute and chronic effects of atrazine on some biochemical parameters in Clarias gariepinus were investigated in this study. Methods: Atrazine toxicity was determined by assessing the responses of glucose, protein, alanine aminotransferase (ALT), ...

Acute and chronic toxicities of the water extract from the dried fruits of Terminalia bellerica (Gaertn.) Roxb. were assessed in both female and male rats. For the study of acute toxicity, a single oral administration of the water extract at a dose of 5,000 mg/kg body weight (10 female, 10 male) was performed and the results showed no signs of toxicity such as general behavior changes, morbidit...

Document Title: Study 200: Protocol for monitoring acute and chronic toxicity in the San Joaquin River watershed, winter 2000-200 1

human brucellosis is a major health problem in developing countries. a number of patients with human brucellosis do not recover from the acute stage of the disease and pass into the chronic form. since the pathophysiology of this change is not well understood, we studied the t-cell subsets during the acute, subacute and chronic forms of human brucellosis. in this study we found alterations in t...

We investigated the toxicity of the fixed oil of Nigella sativa L seeds in mice and rats through determination of LD50 values and examination of possible biochemical, hematological and histopathological changes. The acute toxicity of Nigella sativa fixed oil was investigated in mice. LD50 values, obtained by single doses, orally and intraperitoneally administered in mice, were 28.8 ml/kg body w...