BACKGROUND AND PURPOSE Excessive release of nitric oxide (NO) has been implicated in the pathophysiology of neurodegeneration in ischemic stroke. We compared intracerebral release of indicators of NO generation at the acute and subacute stages of transient focal cerebral ischemia. METHODS In vivo microdialysis in the rat striatum was performed at the acute (first hours) and subacute (after 24...

Whether an acute myocardial infarction due to occlusion of one major coronary artery can cause ischemia in the distribution of a second narrowed coronary artery by the mechanism of collateral interruption (i.e., ischemia at a distance) is not known. To study this, we reviewed 128 consecutively autopsied patients with acute fatal myocardial infarcts and identified 20 patients in whom angina, ass...

OBJECTIVES Previous studies have demonstrated that ischemia-modified albumin (IMA) is a useful marker for the diagnosis of ischemic events. This study aimed to determine the value of ischemia-modified plasma albumin in the early diagnosis of acute mesenteric ischemia in an experimental model. METHODS The study was performed on 32 Wistar albino rats divided into control (n = 8), sham (n = 8), ...

Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. Previous studies showed that ozone oxidative preconditioning (OzoneOP) attenuated renal ischemia/reperfusion injury. The objective of this study was to examine the role of the OzoneOP in modulating inflammation and apoptosis after renal ischemia/reperfus...

Injury of an artery has a significantly worse prognosis for the patient than a venous injury. Blunt injuries of lower limb digital arteries with the development of acute ischemia present a very rare phenomenon. A crush mechanism with a defect of the non-wetted surface of vessel's inner part and the development of subsequent thromboischemic lesion is essential for the development of ischemia. We...