Although overall incidence is rare, leukemia is the most common type of childhood cancer. It accounts for 30% of all cancers diagnosed in children younger than 15 years. Within this population, acute lymphocytic leukemia (ALL) occurs approximately five times more frequently than acute myelogenous leukemia (AML) and accounts for approximately 78% of all childhood leukemia diagnoses. Epidemiologi...

Fifty cases of acute leukemia were analyzed by means of flow cytometry. The results obtained were correlated with morphology and routine cytochemistries. The panel selected was useful in classifying an acute leukemia as acute lymphocytic (ALL) or acute nonlymphocytic (ANLL), which is of primary importance for therapeutic considerations. Common ALL (CALLA) (J5) was a good marker for classifying ...

The activities of enzymes involved in the formation and catabolism of 6-thiopurine nucleotide were assayed in leukocytes of leukemic patients considered either suscepti ble or resistant to the 6-thiopurines. Altered ratios of the activities of hypoxanthine-guanine phosphoribosyltransferase (H-GPRT) and adenine phosphoribosyltransferase were noted in leukocytes from 3 of 11 resistant acute nonly...

A "poroid cell neoplasm" is a general term used to describe nodular tumors that consist of poroid cells and cuticular cells. Eccrine poroma, the most common type neolplasm, tumor continuous with epidermis extends into dermis in cord-like fashion. This almost always seen as single lesion, cases multiple eccrine poromas (eccrine poromatosis) being exceedingly rare. In fact, there have only been a...

Leukemic cells from 20 patients with chronic lymphocytic leukemia (CLL) and 60 patients with acute lymphocytic leukemia (ALL) were studied for T- and B-lymphocyte cell surface membrane markers. B-cell markers included surface membrane immunoglobulin, erythrocyte-antibody complement rosette formation, and B-cell (a-like or HLA-DR) antigens detected by a B-cell antiserum. T-cell markers included ...

The association between a familial history of autoimmune disease and childhood acute leukemia was investigated in a French case-control study that, overall, was designed to assess the role of perinatal, infectious, environmental, and genetic factors in the etiology of childhood acute leukemia. Familial histories of autoimmune disease in firstand second-degree relatives were compared in 279 inci...

Common acute lymphocytic leukemia antigen (CALLA' ; CD10) is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) (references 1-8) . It is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL, and is absent from normal PBMC. However, CALLA is not restricted to leukemic cells and is found on a variety of normal tissues (9-14) . ...

Large granular lymphocytic (LGL) leukemia is a lymphoproliferative disease characterized by the clonal expansion of cytotoxic T or natural killer cells. We report on a patient diagnosed with T-cell LGL leukemia two years after the achievement of hematologic remission for acute myeloblastic leukemia.

The association between a familial history of autoimmune disease and childhood acute leukemia was investigated in a French case-control study that, overall, was designed to assess the role of perinatal, infectious, environmental, and genetic factors in the etiology of childhood acute leukemia. Familial histories of autoimmune disease in first- and second-degree relatives were compared in 279 in...

Despite initial complete remission rates exceeding 70%, the majority of patients with acute myeloid leukemia (AML) and adults with acute lymphocytic leukemia (ALL) eventually relapse. Improving the therapeutic results in acute leukemia requires detecting, and understanding the biology of, the minimal residual leukemia remaining after therapy and responsible for relapse. To investigate the biolo...