نتایج جستجو برای: acute oral toxicology
تعداد نتایج: 741419 فیلتر نتایج به سال:
BACKGROUND Determination of acute toxicity, expressed as median lethal dose (LD50), is one of the most important steps in drug discovery pipeline. Because in vivo assays for oral acute toxicity in mammals are time-consuming and costly, there is thus an urgent need to develop in silico prediction models of oral acute toxicity. RESULTS In this study, based on a comprehensive data set containing...
Evolutionary toxicology is a young field that has grown rapidly in the past two decades. The potential of this field comes from the ability to link chemical contamination to multigenerational and population-wide effects in various species. The advancements and rapidly decreasing costs of -omic tools are improving the power and resolution of evolutionary toxicology studies. In this manuscript, w...
The field of predictive toxicology requires the development of open, public, computable, standardized toxicology vocabularies and ontologies to support the applications required by in silico, in vitro, and in vivo toxicology methods and related analysis and reporting activities. In this article we review ontology developments based on a set of perspectives showing how ontologies are being used ...
Marc A.T. Teunis, Sander W. Spiekstra, Mieke Smits, Els Adriaens, Tobias Eltze, Valentina Galbiati, Cyrille Krul, Robert Landsiedel, Raymond Pieters, Judith Reinders, Erwin Roggen, Emanuela Corsini, Susan Gibbs* 1 University of Applied Sciences, Utrecht, The Netherlands; 2 Dept. Dermatology, VU University Medical Centre, Amsterdam, The Netherlands; 3 Adriaens Consulting, Statistical and Scienti...
Genetic toxicology is the scientific discipline dealing with the effects of chemical, physical and biological agents on the heredity of living organisms. The Internet offers a wide range of online digital resources for the field of Genetic Toxicology. The history of genetic toxicology and electronic data collections are reviewed. Web-based resources at US National Library of Medicine (NLM), inc...
The attitudes and experiences of pathologists and coroners to the provision of biochemical forensic toxicology in the Republic of Ireland were determined using separate questionnaires to each group anonymously. Replies were received from 36/88 (41%) of pathologists and 19/71 (27%) of coroners. 37% of coroners considered that histopathologists give an adequate opinion in forensic toxicology yet ...
This paper surveys recent, as yet unpublished, statistical studies arising from research in genetic toxicology within the U.S. National Toxicology Program (NTP). These studies all involve analyses of data from Ames Salmonella/microsome mutagenicity tests, but the statistical methodologies are broadly applicable. Three issues are addressed: First, what is a tenable sampling model for Ames test d...
Upregulatory Effects of Nobiletin, a Citrus Flavonoid with Anti-dementia Activity, on the Gene Expression of mAChR, ChAT, and CBP Junko Kimura1, Kosuke Shimizu1, Jiro Takito2, Kiyomitsu Nemoto3, Masakuni Degawa3, Akihito Yokosuka4, Yoshihiro Mimaki4, Naoto Oku1, Yasushi Ohizumi1,5 1 Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan 2 ...
Gas chromatography in combination with mass spectrometry (GC-MS) plays an important role in the field of analytical toxicology. The identification of unknown compounds is very frequently undertaken with GC-MS and utilizing mass spectral libraries. Currently available libraries for analytical toxicology were compared for overlapping and uniqueness of their entries. Furthermore, the widely known ...
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